“…[72,73,75,90,91,108] (N im ,N À ,N À ) is the main metal-binding mode experienced by Cu 2+ , although there is no general agreement on the contribution of additional donor atoms. [72,74,89,90,[93][94][95][96][97][98][109][110][111] Structural rearrangement of the N-terminus caused by copper(II) binding has also been studied but conflicting results have been reported for peptides that contain different domains. [112,113] The majority of studies with PrP peptide fragments allowed the assessment of the copper(II) coordination modes, but the results represented a simplified model of the copper-binding chemistry and did not consider important aspects of the metal-PrP interactions because protein folding and interregion interactions were not accounted for.…”