Copper-induced formation of reactive oxygen species causes cell death and disruption of calcium homeostasis in trout hepatocytes

Manzl, Claudia; Enrich, Julia; Ebner, Hannes; Dallinger, Reinhard; Krumschnabel, Gerhard

doi:10.1016/j.tox.2003.11.001

Cited by 104 publications

(62 citation statements)

References 17 publications

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“…In trout hepatocytes, copper exposure leads to cell death through ROS formation (46). In the present study, genes implicated in caspase activity, cell cycle arrest, and cyclin-dependent protein kinase inhibition were significantly upregulated.…”

Section: Molecular Mechanisms Of Copper Toxicitysupporting

confidence: 53%

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Song

Freedman

2009

Physiological Genomics

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Copper is an essential trace element; however, at supraphysiological levels, it can be extremely toxic. Microarray data from HepG2 cells exposed to 100, 200, 400, and 600 μM copper for 4, 8, 12 and 24 h were generated and analyzed. Principal components, K-means, and hierarchical clustering, interactome, and pathway mapping analyses indicated that these exposure conditions induce physiological and toxicological changes in the HepG2 transcriptome. As a general trend, when the level of toxicity increases, the number and diversity of affected genes, Gene Ontology categories, regulatory pathways, and complexity of interactomes increase. Physiological responses to copper include transition metal ion binding and responses to stress/stimulus, whereas toxicological responses include apoptosis, morphogenesis, and negative regulation of biomolecule metabolism. The global gene expression profile was overlaid onto biomolecular interaction networks and signal transduction cascades using pathway mapping and interactome identification. This analysis indicated that copper modulates signal transduction pathways associated with MAPK, NF-κB, death receptor, IGF-I, hypoxia, IL-10, IL-2, IL-6, EGF, Toll-like receptor, protein ubiquitination, xenobiotic metabolism, leukocyte extravasation, complement and coagulation, and sonic hedgehog signaling. These results provide insights into the global and molecular mechanisms regulating the physiological and toxicological responses to metal exposure.

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Section: Molecular Mechanisms Of Copper Toxicitysupporting

confidence: 53%

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Song

Freedman

2009

Physiological Genomics

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“…What is more, in vitro studies conducted recently have shown the ability of copper to initiate oxidizing events that may interfere with important cell activities [7]. Manzl et al [18] conducted a laboratory study on copper toxicology using trout hepatocytes. It has been observed that the presence of copper, induced by calcium loss, causes a consequent loss of liver cell viability.…”

Section: Resultsmentioning

confidence: 99%

Corrosion Damage Investigation of Silver-Soldered Stainless Steel Orthodontic Appliances Used in Vivo / Ocena Zniszczeń Korozyjnych Używanych In Vivo Stałych Aparatów Ortodontycznych O Połączeniach Lutowanych Na Bazie Srebra

Łępicka¹,

Grądzka-Dahlke²,

Szarmach³

2015

Archives of Metallurgy and Materials

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Processes of destruction of products used in orthodontic treatment, e.g. fixed orthodontic appliances, microimplants or dental prostheses considerably limit its operational lifetime and comfort and safety of patients. The objective of the research was to evaluate and assess corrosion damage to silver-soldered stainless steel rapid palatal expansion Hyrax devices. Used in vivo for 2 or 6 months, respectively, RPE (rapid palatal expansion) devices were analyzed macroscopically and in a scanning electron microscope with an energy X-ray analyzer for signs of corrosion. The evaluated appliances showed discernible differences between the overall condition of the noble solders and the stainless steel elements. The Ag-rich solders were chiefly covered in corrosion pits, whereas stainless steel wires, molar bands and Hyrax screws presented corrosion-free surfaces. What is more, the EDS analysis showed differential element composition of the solders. According to the results, noble materials, such as Ag-rich solders, can corrode in a salivary environment when coupled with stainless steel. The selective leaching processes are observed.

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“…Copper may also disrupt enzyme structures and functions by binding to sulfur or carboxylate containing groups and amino groups holes in the cell membranes, thereby compromising the integrity of cells of proteins and can interact with lipids, causing their peroxidation and opening holes in the cell membranes, thereby compromising the integrity of cells. This can cause leakage of essential solutes, which in turn, can have a desiccating effect (Manzl et al, 2004). Copper damages the respiratory chain in Escherichia coli cells and is associated with impaired cellular metabolism (Domek et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Antibacterial Activity of Some Organic and Inorganic Salts Against Asiatic Citrus Canker Agent Xanthomonas Citri Subsp. Citri

Hasabi

Askari

Alavi

et al. 2014

Turkish JAF Sci.Tech.

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Asiatic citrus canker caused by Xanthomonas citri subsp. citri is becoming a disease of high economic impact, affecting all types of important citrus crops. In this study, the potential antibacterial activity of ten organic and inorganic salts on X. citri subsp. citri and on citrus canker disease development was evaluated. Among the salt compounds, copper, iron and zinc inorganic salts particularly zinc (with the highest diameter of inhibition, the lowest MIC and MBC values and the highest bacterial growth inhibitory effect) had direct antibacterial activity and strongly reduced the development of canker disease and bacterial population of lime plants.

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Copper-induced formation of reactive oxygen species causes cell death and disruption of calcium homeostasis in trout hepatocytes

Cited by 104 publications

References 17 publications

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

Corrosion Damage Investigation of Silver-Soldered Stainless Steel Orthodontic Appliances Used in Vivo / Ocena Zniszczeń Korozyjnych Używanych In Vivo Stałych Aparatów Ortodontycznych O Połączeniach Lutowanych Na Bazie Srebra

In Vitro and In Vivo Antibacterial Activity of Some Organic and Inorganic Salts Against Asiatic Citrus Canker Agent Xanthomonas Citri Subsp. Citri

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