Copper-Incorporated Collagen/Catechol Film for in Situ Generation of Nitric Oxide

Luo, Rifang; Liu, Yujie; Yao, Hang; Jiang, Lang; Wang, Jin; Weng, Yajun; Zhao, Ansha; Huang, Nan

doi:10.1021/acsbiomaterials.5b00131

Cited by 32 publications

(32 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduced proliferation of ECs on the crystalline coating (Ti40Cu‐2) may, therefore, be explained by the greater concentration of NO produced by the higher catalytic activity of this sample. Our findings on the inhibition of SMC activity, the suppression of platelet adhesion, and the promotion of EC viability induced by NO are consistent with previous studies that showed NO elicits diametrically opposite effects on these different cell types …”

Section: Resultssupporting

confidence: 93%

“…Prior research has demonstrated that Cu ions initiate NO release from both endogenous and synthetic RSNOs . To validate the role of released Cu ions in the catalytic activity of our Ti–Cu coatings, the samples were immersed in PBS for 30 min to provide a leach solution, and then the concentrations of NO generated by the leach solutions were measured by the Saville–Griess assay.…”

Section: Resultsmentioning

confidence: 99%

“…Physiological synthesis rates of NO from healthy endothelial cells are ≈0.5–4 × 10 −10 mol cm −2 min −1 . Copper‐incorporated collagen/catechol coatings catalytically generate NO with a rate of ≈0.77 × 10 −10 mol cm −2 min −1 . The 1, 5, and 10 wt% copper particle polymers provided NO fluxes that peaked at 5, 10, and 12.4 × 10 −10 mol cm −2 min −1 , respectively .…”

Section: Resultsmentioning

confidence: 99%

“…The potential advantage of employing catalytic surfaces in vivo is that locally enhanced nitric oxide levels are likely to be maintained for extended time periods due to the decomposition of endogenous RSNOs enhanced by the inserted catalytic surface. RSNOs can decompose to release NO in the presence of catalytic agents such as organoselenium, thiol groups, or Cu 2+ ions to improve their hemocompatibility. Copper ions catalyze and initiate NO release from both endogenous and synthetic RSNOs .…”

Section: Introductionmentioning

confidence: 99%

“…RSNOs can decompose to release NO in the presence of catalytic agents such as organoselenium, thiol groups, or Cu 2+ ions to improve their hemocompatibility. Copper ions catalyze and initiate NO release from both endogenous and synthetic RSNOs . NO can be effectively generated from RSNO through the catalytic activity of Cu ions as described by reactions (1–3)

RSNO + 2 {OH}^{-} = {RS}^{-} + {NO}_{2}^{-} + {normalH}_{2} O

2 {Cu}^{2 +} + 2 {RS}^{-} = 2 {Cu}^{+} + RSSR

{Cu}^{+} + RSNO = {Cu}^{2+} + {RS}^{-} + NO

…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Catalytic Formation of Nitric Oxide Mediated by Ti–Cu Coatings Provides Multifunctional Interfaces for Cardiovascular Applications

Wang

Akhavan

Jing

et al. 2018

Adv Materials Inter

Self Cite

View full text Add to dashboard Cite

An ideal surface of a cardiovascular device, such as a stent, must be multifunctional: promoting endothelialization to regenerate the vessel's natural endothelial cell (EC) lining; inhibiting the proliferation of smooth muscle cells that occlude vessels; and simultaneously mitigating thrombosis that leads to the spontaneous formation of blood clots. Here it is reported on Ti–Cu interfaces that demonstrate this required multifunctionality through the controlled release of copper ions that induce the catalytic formation of nitric oxide (NO). Ti–Cu coatings, deposited on stainless steel substrates via direct current magnetron sputtering, demonstrate a significantly higher NO‐release catalytic activity compared to Ti coatings due to release of copper ions. Ti–Cu surfaces that stimulate optimum catalytic formation of NO significantly decrease smooth muscle cell proliferation, inhibit platelet adhesion, and improve endothelial cell EC compatibility. The development of such catalytic surfaces through a simple sputtering method holds great promise for the fabrication of advanced multifunctional cardiovascular devices such as stents and coronary implants.

show abstract

Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

RSNO + 2 {OH}^{-} = {RS}^{-} + {NO}_{2}^{-} + {normalH}_{2} O

2 {Cu}^{2 +} + 2 {RS}^{-} = 2 {Cu}^{+} + RSSR

{Cu}^{+} + RSNO = {Cu}^{2+} + {RS}^{-} + NO

…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Catalytic Formation of Nitric Oxide Mediated by Ti–Cu Coatings Provides Multifunctional Interfaces for Cardiovascular Applications

Wang

Akhavan

Jing

et al. 2018

Adv Materials Inter

Self Cite

View full text Add to dashboard Cite

show abstract

Versatile Surface Modification Using Polydopamine and Related Polycatecholamines: Chemistry, Structure, and Applications

Barclay

Hegab

Clarke

et al. 2017

Adv Materials Inter

278

222

View full text Add to dashboard Cite

Almost ten years ago, Lee et al. [13] formulated a universal adhesive coating based on observation of the strong attachment by mussels through their byssal threads to virtually all types of inorganic and organic surfaces. The amino acid compositions of the mussel foot proteins that generate the attachment are rich in catechol and amine groups. [13][14][15] These groups associate under marine conditions, forming strong covalent and noncovalent interactions with substrates. [13] This led to the idea that both catechol and amine groups were crucial in forming robust, wide spectrum adhesive nanolayers [16,17] and consequently dopamine was conceived as a powerful building block for spontaneous deposition of thin polymer films. The dopamine monomer is deposited onto unadulterated surfaces through self-assembly and oxidative cross-linking from mild pH aqueous solution in a rapid reaction. This results in a durable, nanoscale, conformal, and hydrophilic coating that can be readily modified to introduce specific surface chemistries for a particular application. [18][19][20][21][22] These bioinspired, polydopamine materials are chemically and structurally indistinguishable from eumelanins found in the human body, [23,24] providing excellent biocompatibility. Additionally, polydopamine has broad electromagnetic absorption and excellent photothermal energy conversion [25] as well as having ionic-electronic hybrid conductivity. [26] Along with the excellent coating performance, these properties provide a vast array of potential applications for polydopamine materials.In this article, we explain what is known about polydopamine and related catecholamine coatings; their formation, the adhesion mechanism, and their physicochemical properties and we also review the applications of these materials (Figure 1). Since 2011, there have been a number of reviews on this subject matter, including general reviews on the physicochemical properties of polydopamine coatings [11,20,[27][28][29] and their applications. [20,27,30] There are also a number of more specific reviews on the chemical synthesis and modulation of polycatecholamine coatings, [31] the biomedical applications of these coatings, [8,[32][33][34] their electronic properties, [26,35] the use of polydopamine to make films at fluid interfaces, [36] in hierarchically constructed particles, [33] and capsules, [30] exploitation of polycatecholamine coatings in membrane filtration, [37] polydopamine-derived carbon materials, [38] and the use of coordination chemistry in catechol-based materials. [39] Nonetheless, this area of research is growing so rapidly [25,27] that many recent Polydopamine and related polycatecholamines can be easily deposited onto almost any surface from mild, aqueous solution. This results in durable, nanoscale coatings that exhibit high biocompatibility and have useful chemical and electronic properties. Additionally, these materials can be readily chemically and physically modified, and consequently, they are used extensively for surface modification. This ...

show abstract

Substrate mediated enzyme prodrug therapy

Fejerskov

Olesen

Zelikin

2017

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Substrate mediated enzyme prodrug therapy (SMEPT) is a biomedical platform developed to perform a localized synthesis of drugs mediated by implantable biomaterials. This approach combines the benefits and at the same time offers to overcome the drawbacks for traditional pill-based drug administration and site-specific, implant mediated drug delivery. Specifically, SMEPT offers the flexibility of delivering multiple drugs - individually as monotherapy, in sequence, or as a combination therapy, all of which is also accomplished in a site-specific manner. This technology is also unique for site-specific synthesis of drugs with short half-life, such as nitric oxide. This review presents historical development of SMEPT from early reports to the most recent examples, and also outlines potential avenues for subsequent development of this platform.

show abstract

Copper-Incorporated Collagen/Catechol Film for in Situ Generation of Nitric Oxide

Cited by 32 publications

References 51 publications

Catalytic Formation of Nitric Oxide Mediated by Ti–Cu Coatings Provides Multifunctional Interfaces for Cardiovascular Applications

Catalytic Formation of Nitric Oxide Mediated by Ti–Cu Coatings Provides Multifunctional Interfaces for Cardiovascular Applications

Versatile Surface Modification Using Polydopamine and Related Polycatecholamines: Chemistry, Structure, and Applications

Substrate mediated enzyme prodrug therapy

Contact Info

Product

Resources

About