Copper in airborne fine particulate matter (PM2.5) from urban sites causes the upregulation of pro-inflammatory cytokine IL-8 in human lung epithelial A549 cells

Amma, Chisato; Inomata, Yayoi; Kohno, Risa; Satake, Masahiro; Furukawa, Akinori; Nagata, Yasunobu; Sugiyama, Hironori; Seto, Takafumi; Suzuki, Ryo

doi:10.1007/s10653-023-01599-4

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…Air pollution is a major problem that has been increasing due to industrial and technological development and is the fourth leading cause of death worldwide, with 6.7 million deaths each year [1]. Atmospheric particulate matter (PM) is a complex composite of heavy metals, inorganic compounds, water soluble secondary inorganic compounds (sulphates, nitrates and ammonia), organic compounds (HAPs and COVs), and elemental carbon [2][3][4][5][6][7][8]. PM is one of the most dangerous atmospheric pollutants, with very harmful effects on human health.…”

Section: Introductionmentioning

confidence: 99%

Development of Cellulose Air Filters for Capturing Fine and Ultrafine Particles through the Valorization of Banana Cultivation Biomass Waste

Martín-Cruz,

Bordón,

Pulido-Melián

et al. 2024

Environments

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Outdoor and indoor atmospheric pollution is one of the major problems that humanity continues to face. As a mitigation pathway, numerous technologies have been developed for air purification, including the use of fibrous filters. In this study, the particle capture efficiencies and pressure drops of air filters manufactured with cellulose pulp extracted from banana pseudostems were studied across three particle size ranges (PM10, PM2.5, and PM1). Two pretreatments were applied, alkaline with soda-antraquinone (alkali-treated pulp) and a subsequent bleaching process (bleached pulp), and four manufacturing processes were tested: crushing, freeze-drying, vacuum filtration, and pressing. In addition, a study varying filter grammage (70, 100, and 160 g·m−2) and pressing pressures (2, 4, 6, and 8 t) was also performed. After conducting these particle tests, the filter manufactured with bleached pulp, having a grammage of 160 g·m−2 and pressed at 4 t, was deemed the optimal individual solution. It demonstrated high particle retention efficiencies across all particle size ranges (with values exceeding 80%), a moderate pressure drop below 1000 Pa, and high thermal stability (degradation above 220 °C). However, combining freeze-drying and two-ton pressing processes yielded improved results (83% for the smallest particles and 89% for others) with approximately half the pressure drop. Based on these results, this study stands as a noteworthy contribution to waste valorization and the advancement of environmentally friendly materials for particle air filters. This is achieved through the adoption of simple and cost-effective technology, coupled with the utilization of 100% natural agricultural waste as the primary manufacturing material.

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Section: Introductionmentioning

confidence: 99%

Development of Cellulose Air Filters for Capturing Fine and Ultrafine Particles through the Valorization of Banana Cultivation Biomass Waste

Martín-Cruz,

Bordón,

Pulido-Melián

et al. 2024

Environments

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“…8 It has been reported that PM 2.5 causes the upregulation of IL-8 in human lung epithelial A549 cells. 9 Also, PM 2.5 promotes the progression of non-small cell lung cancer (NSCLC) by enhancing cancer proliferation and metastasis via the IL-17a signaling. 10 Understanding the underlying molecular mechanism will confer a novel insight for the treatment of fine-particle-interrelated diseases, especially tumor metastasis.…”

mentioning

confidence: 99%

“…PM 2.5 has been demonstrated to promote or progress triple-negative breast cancer (TNBC) and increase the malignancy of TNBC . It has been reported that PM 2.5 causes the upregulation of IL-8 in human lung epithelial A549 cells . Also, PM 2.5 promotes the progression of non-small cell lung cancer (NSCLC) by enhancing cancer proliferation and metastasis via the IL-17a signaling .…”

mentioning

confidence: 99%

Air–Liquid Interface Microfluidic Monitoring Sensor Platform for Studying Autophagy Regulation after PM2.5 Exposure

Zheng,

Yang,

Xue

et al. 2024

ACS Sens.

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Undoubtedly, a deep understanding of PM 2.5 -induced tumor metastasis at the molecular level can contribute to improving the therapeutic effects of related diseases. However, the underlying molecular mechanism of fine particle exposure through long noncoding RNA (lncRNA) regulation in autophagy and, ultimately, lung cancer (LC) metastasis remains elusive; on the other hand, the related monitoring sensor platform used to investigate autophagy and cell migration is lacking. Herein, this study performed an air−liquid interface microfluidic monitoring sensor (AIMMS) platform to analyze human bronchial epithelial cells after PM 2.5 stimulation. The multiomics analysis [RNA sequencing (RNA-seq) on lncRNA and mRNA expressions separately] showed that MALAT1 was highly expressed in the PM 2.5 treatment group. Furthermore, RNA-seq analysis demonstrated that autophagy-related pathways were activated. Notably, the main mRNAs associated with autophagy regulation, including ATG4D, ATG12, ATG7, and ATG3, were upregulated. Inhibition or downregulation of MALAT1 inhibited autophagy via the ATG4D/ATG12/ATG7/ATG3 pathway after PM 2.5 exposure and ultimately suppressed LC metastasis. Thus, based on the AIMMS platform, we found that MALAT1 might become a promising therapeutic target. Furthermore, this low-cost AIMMS system as a fluorescence sensor integrated with the cell-monitor module could be employed to study LC migration after PM 2.5 exposure. With the fluorescence cell-monitoring module, the platform could be used to observe the migration of LC cells and construct the tumor metastasis model. In the future, several fluorescence probes, including nanoprobes, could be used in the AIMMS platform to investigate many other biological processes, especially cell interaction and migration, in the fields of toxicology and pharmacology.

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Association of multiple blood metals and systemic atherosclerosis: A cross-sectional study in the CAD population

Sun,

Mao,

Zhou

et al. 2024

Chemosphere

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Copper in airborne fine particulate matter (PM2.5) from urban sites causes the upregulation of pro-inflammatory cytokine IL-8 in human lung epithelial A549 cells

Cited by 4 publications

References 40 publications

Development of Cellulose Air Filters for Capturing Fine and Ultrafine Particles through the Valorization of Banana Cultivation Biomass Waste

Development of Cellulose Air Filters for Capturing Fine and Ultrafine Particles through the Valorization of Banana Cultivation Biomass Waste

Air–Liquid Interface Microfluidic Monitoring Sensor Platform for Studying Autophagy Regulation after PM2.5 Exposure

Association of multiple blood metals and systemic atherosclerosis: A cross-sectional study in the CAD population

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