Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers

Vegas, Verónica G.; Lorca, Romina; Latorre, Ana; Hassanein, Khaled; Gómez‐García, Carlos J.; Castillo, Óscar; Somoza, Álvaro; Zamora, Félix; Amo‐Ochoa, Pilar

doi:10.1002/ange.201609031

Cited by 3 publications

(4 citation statements)

References 24 publications

(15 reference statements)

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“…More recently, perspectives on the use of metal–organic colloids are changing, as it has been demonstrated by Vegas et al [ 18 ], who showed the synthesis of a 1D-Cu(II) antiferromagnetic coordination polymer (CP) with modified thymine (thymine-1-acetic acid, TAcOH). Thanks to the insolubility in the aqueous medium where it is obtained, this 1D-CP can be generated in nanoribbons forming a stable colloidal suspension for long periods.…”

Section: Colloid Dispersions Based On Coordination Bonds With Interesting Biological Ligandsmentioning

confidence: 99%

“… One-dimensional Cu(II) coordination polymer ( A ) as colloidal suspension of nanometric dimensions ( C ), with low toxicity versus different cancer cell lines (C918, PANC-1, and HaCaT) ( B ) and with selectivity versus adenine oligonucleotide ( D ). Adapted from reference [ 18 ] with permission, copyright 2019 John Wiley and Sons, Inc. …”

Section: Figurementioning

confidence: 99%

“…This kind of new bioinspired coordination compounds will lead to the development of biomimetic and biocompatible metal–organic gels/aerogels [ 14 , 15 ] with low toxicity. Furthermore, this new type of metal–organic gels or aerogels will likely provide innovative applications in 3D printing technologies [ 16 , 17 ] or as nanocarrier systems [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Advances and Novel Perspectives on Colloids, Hydrogels, and Aerogels Based on Coordination Bonds with Biological Interest Ligands

Maldonado

Amo‐Ochoa

2021

Nanomaterials

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This perspective article shows new advances in the synthesis of colloids, gels, and aerogels generated by combining metal ions and ligands of biological interest, such as nucleobases, nucleotides, peptides, or amino acids, among other derivatives. The characteristic dynamism of coordination bonds between metal center and biocompatible-type ligands, together with molecular recognition capability of these ligands, are crucial to form colloids and gels. These supramolecular structures are generated by forming weak van der Waals bonds such as hydrogen bonds or π–π stacking between the aromatic rings. Most gels are made up of nano-sized fibrillar networks, although their morphologies can be tuned depending on the synthetic conditions. These new materials respond to different stimuli such as pH, stirring, pressure, temperature, the presence of solvents, among others. For these reasons, they can trap and release molecules or metal ions in a controlled way allowing their application in drug delivery as antimicrobial and self-healable materials or sensors. In addition, the correct selection of the metal ion enables to build catalytic or luminescent metal–organic gels. Even recently, the use of these colloids as 3D-dimensional printable inks has been published. The elimination of the solvent trapped in the gels allows the transformation of these into metal–organic aerogels (MOAs) and metal–organic xerogels (MOXs), increasing the number of possible applications by generating new porous materials and composites useful in adsorption, conversion, and energy storage. The examples shown in this work allow us to visualize the current interest in this new type of material and their perspectives in the short-medium term. Furthermore, these investigations show that there is still a lot of work to be done, opening the door to new and interesting applications.

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Section: Colloid Dispersions Based On Coordination Bonds With Interesting Biological Ligandsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advances and Novel Perspectives on Colloids, Hydrogels, and Aerogels Based on Coordination Bonds with Biological Interest Ligands

Maldonado

Amo‐Ochoa

2021

Nanomaterials

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“…In comparison with other natural nucleobases, the coordination chemistry of thymine-based metal complexes has been much less investigated. Most of the thymine-containing complexes have been prepared with the nucleobase in form of thyminate anion, that is, releasing one or two protons of its N-H groups, whereas the reported examples obtained with the thymine molecule acting through its carbonyl groups as a neutral ligand toward the metal are much scarcer [4][5][6][7]. In that respect, theoretical studies have been performed on metal clusters to investigate preferential binding sites of the thymine molecule [8].…”

Section: Introductionmentioning

confidence: 99%

A Gadolinium(III) Complex Based on the Thymine Nucleobase With Properties Suitable for Magnetic Resonance Imaging Applications

Orts-Arroyo¹,

Ten-Esteve²,

Ginés-Cárdenas³

et al. 2021

Preprint

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The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through vis-IR, SEM-EDAX and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast enhanced magnetic resonance imaging.

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Gas Sensors Based on Copper‐Containing Metal‐Organic Frameworks, Coordination Polymers, and Complexes

López-Molino

Amo‐Ochoa

2020

ChemPlusChem

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In the last years, chemical research has allowed the obtainment of a large number of new sensing compounds useful in diverse interest areas related to health, environment, food, automotive, and steel industries, among others. Taking into account the interest and demand of sensors on a large scale and the urgent need to reduce the size of devices to nanometric scale, coordination compounds (CCs) ‐and more specifically those based on copper‐ have gained full acceptance. CCs present exciting characteristics such as (i) dynamic structures, (ii) ability to form an immense variety of porous structures, or (iii) easy nano processing. Besides, copper is abundant, and an essential ion in the human body with no high toxicity at reachable detectable concentrations. Just this one element copper allows us to obtain porous, non‐porous, optoelectronics, and/or magnetic‐sensitive compounds that can detect a highly varied range of gases in different devices at economical costs. Several studies show how the properties of this type of compounds can be improved depending on their synthesis conditions or by the technology used in the sensor fabrication.

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Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers

Cited by 3 publications

References 24 publications

Advances and Novel Perspectives on Colloids, Hydrogels, and Aerogels Based on Coordination Bonds with Biological Interest Ligands

Advances and Novel Perspectives on Colloids, Hydrogels, and Aerogels Based on Coordination Bonds with Biological Interest Ligands

A Gadolinium(III) Complex Based on the Thymine Nucleobase With Properties Suitable for Magnetic Resonance Imaging Applications

Gas Sensors Based on Copper‐Containing Metal‐Organic Frameworks, Coordination Polymers, and Complexes

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