Copper(II)-MOF Containing Glutarate and 4,4′-Azopyridine and Its Antifungal Activity

Yang, So Hyeon; Veerana, Mayura; Yu, Nan-Nan; Ketya, Wirinthip; Park, Gyungsoon; Kim, Sungjin; Kim, Youngmee

doi:10.3390/app12010260

Cited by 9 publications

(2 citation statements)

References 54 publications

(72 reference statements)

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“…The design of synthetic antimicrobial peptides (SAMPs) represents a different solution to counteract these disadvantages since they show low or no toxicity to mammalian cells and reduced probability to develop antimicrobial resistance [ 36 , 37 ]. Aside from SAMPs, in recent years, further studies have demonstrated the importance of nanozymes as novel therapeutic agents to overcome bacterial and fungal resistance [ 38 ], and the application of metal organic frameworks (MOFs) that can be used as bioactive framework materials (BioMOFs) containing antimicrobial agents with improved antibacterial and antifungal activity [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

A Novel Peptide with Antifungal Activity from Red Swamp Crayfish Procambarus clarkii

et al. 2022

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The defense system of freshwater crayfish Procambarus clarkii as a diversified source of bioactive molecules with antimicrobial properties was studied. Antimicrobial activity of two polypeptide-enriched extracts obtained from hemocytes and hemolymph of P. clarkii were assessed against Gram positive (Staphylococcus aureus, Enterococcus faecalis) and Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria and toward the yeast Candida albicans. The two peptide fractions showed interesting MIC values (ranging from 11 to 700 μg/mL) against all tested pathogens. Polypeptide-enriched extracts were further investigated using a high-resolution mass spectrometry and database search and 14 novel peptides were identified. Some peptides and their derivatives were chemically synthesized and tested in vitro against the bacterial and yeast pathogens. The analysis identified a synthetic derivative peptide, which showed an interesting antifungal (MIC and MFC equal to 31.2 μg/mL and 62.5 μg/mL, respectively) and antibiofilm (BIC50 equal to 23.2 μg/mL) activities against Candida albicans and a low toxicity in human cells.

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Section: Discussionmentioning

confidence: 99%

A Novel Peptide with Antifungal Activity from Red Swamp Crayfish Procambarus clarkii

et al. 2022

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“…Over the past two decades or so, novel types of highly porous materials called metal–organic frameworks (MOFs), prepared in the nanodimensions and microdimensions, were developed and showed a large number of applications, including eradication of bacteria , and fungi , for medical (for instance, photodynamic (PDT) and photothermal (PTT) therapy) and agricultural purposes. , For the detection of viruses using MOFs, which is largely based on biosensing and diagnosing techniques, the field is still relatively in its infancy, but since 2020, literature has also experienced a significant increase in interest and the number of reported studies on these various topics has significantly increased (Figure ). Recently, a review article on biosensing and diagnosing viruses with the use of MOFs was reported, but the management and control of viruses by isolation and elimination was strikingly overlooked.…”

Section: Introductionmentioning

confidence: 99%

Virus Management Using Metal–Organic Framework-Based Technologies

Boivin

Harvey

2023

ACS Appl. Mater. Interfaces

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The eradication and isolation of viruses are two concurrent approaches to protect ourselves from viral infections and diseases. The quite versatile porous materials called metal− organic frameworks (MOFs), have recently emerged as efficient nanosized tools to manage viruses, and several strategies to accomplish these tasks have been developed. This review describes these strategies employing nanoscale MOFs against SARS-CoV-2, HIV-1, tobacco mosaic virus, etc., which include the sequestration by host−guest penetration inside pores, mineralization, design of a physical barrier, controlled delivery of organic and inorganic antiviral drugs or bioinhibitors, photosensitization of singlet oxygen, and direct contact with inherently cytotoxic MOFs.

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Synergistic Antifungal Activity of Dialdehyde Chitosan Loaded with Copper Metal‐Organic Framework (Cu‐MOF)

Kiprono Kirui,

Shigwenya Madivoli,

Mwanza Nzilu

et al. 2024

ChemistrySelect

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Fungal resistance and the environmental degradation posed by conventional fungicides necessitate the need to develop new antifungal agents that can inhibit fungal growth. This study sought to prepare biofungicides by leveraging on the antifungal activity of copper‐metal organic framework (Cu‐MOF) and dialdehyde chitosan (Cs) isolated from black soldier flies (BSF). Cs were oxidized using potassium periodate to obtain dialdehyde Cs (OCs) and thereafter, Cu‐MOF was loaded resulting in Cu‐MOF‐OCs. Fourier Transform Infrared spectrophotometer (FT‐IR) and powder X‐ray diffraction (XRD) confirmed the presence of carbonyl functional groups in OCs and sharp intense peaks associated with Cu that interacted. The changes in surface morphology and the presence of Cu in the MOFs as obtained with Scanning Electron Microscope‐ Energy Dispersive X‐ray (SEM‐EDX), indicated the successful loading of Cu‐MOF on the oxidized Cs. Thermogravimetric analysis (TGA) showed a loss of approximately 31.51 % of the loaded OCs and 40.72 % framework around ∼200 to ∼300 °C and ∼410 to ∼475 °C respectively. The antifungal activity of OCs, Cu‐MOF, and Cu‐MOF‐OCs against Aspergillus brasiliensis and Candida albicans was performed using the plate count method and the results suggested that MOF modulated the antifungal activity exerted by the OCs.

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Copper(II)-MOF Containing Glutarate and 4,4′-Azopyridine and Its Antifungal Activity

Cited by 9 publications

References 54 publications

A Novel Peptide with Antifungal Activity from Red Swamp Crayfish Procambarus clarkii

A Novel Peptide with Antifungal Activity from Red Swamp Crayfish Procambarus clarkii

Virus Management Using Metal–Organic Framework-Based Technologies

Synergistic Antifungal Activity of Dialdehyde Chitosan Loaded with Copper Metal‐Organic Framework (Cu‐MOF)

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