Copper(II) interactions with non-steroidal anti-inflammatory agents. III – 3-Methoxyanthranilic acid as a potential OH-inactivating ligand: A quantitative investigation of its copper handling role in vivo

Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases

“…However, the ANA-Cu 2+ complex increases the Fenton reactivity of copper, producing more hydroxyl radicals, which are quickly removed by the same complex [130, 131]. Due to this property, the synthetic derivative of ANA, 3-methoxyanthranilate, has been proposed as a potential anti-inflammatory drug [132]. …”

N(4)-tolyl-2-benzoylpyridine thiosemicarbazones and their copper(II) complexes with significant antifungal activity: crystal structure of N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone

“…[4][5][6] Copper(II) complexes have found possible medical uses in the treatment of many diseases including cancer and microbial infections. 7 Copper(II) complexes of N(4)-substituted 2-benzoylpyridine thiosemicarbazones have been tested against the human pathogenic fungi Aspergillus niger and Paecillomyces variotii. 8 In the present work we describe the preparation of new copper(II) complexes of N(4)-ortho (H2Bz4oT, hereafter named HL1), N(4)-meta (H2Bz4mT, HL2) and N(4)-para-tolyl-2-benzoylpyridine thiosemicarbazone (H2Bz4pT, HL3, Figure 1).…”

Copper(II) interaction with 3,5-diisopropylsalicylic acid (Dips): New insights on its role as a potential OH inactivating ligand

“…B 1g transitions in the benzene ring, corrected by the bathochromic shift due to the auxochromic 1,2-substituted groups. With reference to the UV-vis spectra of anthranilic acid [6], the OH auxochromic group, compared to the NH 2 group, has a higher bathochromic shift on the E bands than on the B band. The presence of isopropyl groups on the aromatic skeleton of salicylic acid, as expected, increases the bathochromic shifts of all the p !…”

“…Unfortunately, reactivity studies in order to better understand the anti-inflammatory properties of Dips, such as the determination of the redox potential and the detection of the hydroxyl radical production [6,41], are precluded by complex precipitation at inflammatory pH (5.5) and poorly representative at pH 7.4. The attempts made in this respect in SDS aqueous solutions have had limited success.…”

“…The results of these studies have been reviewed [1,3] and confirm that many complexing agents, which are pharmacologically inactive by themselves, display anti-inflammatory properties in association with copper(II) [1,4], such as anthranilic acid [5] and its methoxy derivatives [6].…”