Copper(II) complexes with norfloxacin and neutral terpyridines: Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction approach

Synthesis, characterization and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’‐substituted terpyridine

“…Peaks of Pd(II) complex 2 at 244 and 278 nm were assigned to the π–π * IL transition and the 349 and 365 nm absorptions were assigned to MLCT transition . The bands of Cu(II) and Zn(II) complexes ( 3 , 4 , 5 , 6 , 7 , 8 ) between 223 and 286 nm were assigned to IL transition and 326–334 nm absorption bands were assigned to MLCT transition . The red shift indicated that the metal coordinated with the ligand through nitrogen atoms.…”

“…synthesized copper(II) complexes with terpyridyl and phenanthroline bases in a distorted square‐pyramidal coordination geometry; these copper(II) complexes showed significant cytotoxicity with low IC 50 value. Patel et al . reported some copper(II) complexes based on tpy and norfloxacin, and all the complexes exhibited good cytotoxic activity.…”

“…Metal complexes of tpy can efficiently intercalate into nucleic acid to be effectively performed as potential antitumor agents . Modification of tpy generated a variety of derivatives and structural variation of tpy may have a significant impact on the antitumor activity of their complexes . In order to further explore the structure–activity relationships and discover new metal‐based anticancer drugs, the synthesis, characterization and cytotoxicity of eight new metal (Pt(II), Pd(II), Cu(II) and Zn(II)) complexes with 4’‐substitued tpy are described in the present work for the first time.…”

Crystal structures of o , o ′-( N , N ′-dipicolinyldene)diazadiphenyl disulfide and its copper (II) complex: Antioxidant, antibacterial and DNA-binding properties

“…Schiff bases are known to possess a diverse spectrum of antimicrobial properties and hence it is worthwhile to study the activities of L-L and 1 against a series of bacteria because they can achieve resistance to antibiotics through biological and morphological modifications [33]. Table 4 that both compounds tested showed moderate to good antibacterial activities against all the pathogens tested.…”

Production of Diethyl Terephthalate from Biomass‐Derived Muconic Acid

“…Therefore, considerable endeavors of Cu, Zn‐SOD mimics are carried out towards obtaining stable, nontoxic and inexpensive low‐molecular biomimetic molecules, which are able to catalyze superoxide dismutation and to provide important therapeutic applications 8. Many copper(II) mono/di complexes as the models for the active site of Cu, Zn‐SOD were reported, however, the SOD‐like activities of almost all mimics were relatively low because that the highest SOD‐like activity of reported mimics is about 20 % of the bovine erythrocyte Cu, Zn‐SOD 9–15. As shown in Scheme , the activity of the enzyme is correlated by the structure of the active site and the near weak interactions including the hydrophobic interaction and Arg141 electrostatic force toward the substrate 16…”