Copper(II) complexes with meclofenamate ligands: Structure, interaction with DNA and albumins, antioxidant and anticholinergic activity

Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules

“…Promising compounds, such as metal-based drugs, have been proposed to act on different molecular targets and to contribute to the treatment of neurodegenerative diseases [ 116 ]. This fact, along with our previously reported results on metal complexes with anticholinergic activity [ 75 , 76 ], has led to the study of the anticholinergic activity of the synthesized ferric complexes.…”

“…The UV-vis spectra of the complexes were recorded both in the solution (i.e., in DMSO, as well as in the presence of the buffer solution used in the DNA/albumin interaction studies) and in a solid state (as nujol mull) in order to explore all possible changes upon dilution. The similarity of the spectra suggests that complexes 1 – 3 keep the same structure in the solution [ 22 , 46 , 51 , 52 , 63 , 73 , 75 , 76 , 77 ]. One band located at λ max = 490–515 nm (ε = 400–580 M −1 cm −1 ) is observed in the visible region of the spectrum, which may be attributed to a d–d transition or a 6 A 1g → 5 T 1g or 6 A 1g → T 2g (G) transition [ 106 ], which are characteristic for distorted octahedral Fe 3+ complexes [ 107 , 108 ].…”

“…Its levels and function increase to 105–165% of normal levels, making it the major metabolic enzyme of acetylcholine. It is important therefore to assess the inhibition of each cholinesterase for the different stages of AD [ 75 , 76 ].…”

“…In addition to the synthesis and the structural characterization of complexes 1 – 3 , the main goal of the current research is focused on the assessment of the potential biological activity of the complexes, including their antioxidant capacity and their inhibitory effectiveness towards cholinesterase enzymes. The application of NSAIDs and their compounds as analgesic, anti-inflammatory, and anticholinergic medications is often related to free radicals scavenging [ 22 , 74 , 75 , 76 , 77 ]. Therefore, the antioxidant capacity of the complexes was evaluated in vitro by determining their ability to scavenge 1,1-diphenyl-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radicals.…”

Grid‐Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions

“…The inhibitor's mechanism of action depends strictly on its structure and rely on interaction with the CAS and/or the PAS through multiple modes of interactions. [4,8] So far, the inhibitory properties against the aforementioned enzymes have been studied for metal complexes of silver, [9] nickel, [10] ruthenium [11] or copper, [12] as well as for neutral, purely organic systems. [13] However, one of the most promising examined group of inhibitors are cationic organic compounds containing quaternary pyridinium or ammonium functional moieties.…”