Copper(II) complexes of terpyridine derivatives: A footstep towards development of antiproliferative agent for breast cancer

Synthesis, structural characterization and cytotoxic activity of ternary copper(II)–dipeptide–phenanthroline complexes. A step towards the development of new copper compounds for the treatment of cancer

“…Among the six studied complexes, [Cu(Ala-Phe)(phen)], C3, presents the higher activity, with IC 50 values comparable or lower to those presented by other complexes catalogued as promising antitumor agents [3,[38][39][40]. Moreover, C3 induces MCF-7 cell death at an IC 50 = 1 μM being more active than Cisplatin which Table 4 Wavenumber (cm −1 ) of common bands in the complexes and in the free phen, as well as their tentative vibrational assignment.…”

Characterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridine

“…Other ligands, such as terpyridine, are also able to improve the stability of copper complexes and promote insertion of either planar pyridyl or aromatic ring between base pairs of the DNA, where the copper acts both as an anchor and reactive agent [5,16,17]. Considering copper and terpyridine properties, the synthesis and chemical characterization of a copper compound [Cu(H 2 O){OS(CH 3 ) 2 }L](NO 3 ) 2 incorporating the ligand 4′-phenyl-terpyridine (l) (named ZM5 in this work) (Fig.…”

DNA interaction and cytotoxic activity of copper complex based on tridentate hydrazone derived ligand and nitrogen donor heterocycle

“…68 P.R. Inamdar et al / Inorganic Chemistry Communications 67 (2016) 67-71was observed, probably, due to perturbations in the base stacking behavior of DNA supporting intercalative binding pattern, while, groove binding mode never alters the base stacking and helical structure of the DNA [35,36]. In order to understand the forces involved in the interactions, an acridine orange fluorescence displacement assay (Fig.…”

“…S11). But, with increased concentration of the complex (100 μM), a marked increase in the positive band by 1 nm was observed, probably, due to perturbations in the base stacking behavior of DNA supporting intercalative binding pattern, while, groove binding mode never alters the base stacking and helical structure of the DNA [35,36].…”