Copper(II) complexes of N 3 O tripodal ligands appended with pyrene and polyamine groups: Anti-proliferative and nuclease activities

Anti-Proliferation and DNA Cleavage Activities of Copper(II) Complexes of N3O Tripodal Polyamine Ligands

“…It is worth noting that the pKa values of 2, 3, and 4 (referred to one proton in the latter case, e.g., 4.38) are in a narrow range, consistent with a similar electronic effect of the phenol para substituent (same alkyl ammonium chain). It should be emphasized that these pKa values are 0.22 to 0.48 units higher than for analogous methyl complexes [44]. We interpret this increase in pKa by a decrease in Lewis acidity at the metal center due to the greater electron-donating capacity of the methoxy-substituted pyridine.…”

“…The methoxypyridine is positioned apically, but this group is almost uncoordinated (Cu-N1 bond distance of 2.773(5) Å). This behavior is in sharp contrast with the methylpyridine analog of Me 1 that binds apically at a much shorter Cu-N1 bond distance of 2.303(2) Å [44]. The Cu-N3, Cu-N2, Cu-O1, and Cu-Cl bond distances are 2.034(3), 2.017(3), 1.902(3), and 2.251(1) Å, respectively.…”

“…Although these properties are key points for complex activity, the relative influence of the two on nuclease activity is currently unknown. We have further demonstrated that both nuclease activity and antiproliferative activity against bladder tumor cell lines can be enhanced by the addition of a putrescine chain and a pyrene moiety [43,44]. This functionalization pattern increases the affinity for DNA by both ionic interactions between the putrescine chain and the negatively charged phosphates, and intercalation of the pyrene moiety between consecutive base pairs.…”

“…The structure of 1 shows a square pyramidal copp ter where the tertiary amine nitrogen N3, the pyridine nitrogen N2, the phenolate O1, and the chloride Cl coordinate in the basal plane. The methoxypyridine is pos apically, but this group is almost uncoordinated (Cu-N1 bond distance of 2.773 (5) behavior is in sharp contrast with the methylpyridine analog of Me 1 that binds ap a much shorter Cu-N1 bond distance of 2.303(2) Å [44]. The Cu-N3, Cu-N2, Cu-O Cu-Cl bond distances are 2.034(3), 2.017(3), 1.902(3), and 2.251(1) Å, respectively.…”

Positively Charged and pH‐sensitive Carbon Dots for Fluorescence Detection of Copper Ion

“…Copper ion (Cu 2+ ) can work as catalytic cofactors for various metalloenzymes, such as superoxide dismutase, 1,2 cytochrome c oxidase, 3 tyrosinase, 4,5 and nuclease, 6,7 which play an important role in the physiological and pathological processes of living systems, thereby making itself as a biologically essential trace element. 8,9 Cu 2+ has been widely applied to various industrial fields, such as chemistry and materials science, thereby making our life convenient.…”