Copper(II) complexes of hydroxyflavone derivatives as potential bioactive molecule to combat antioxidants: synthesis, characterization and pharmacological activities

Nagashri, K.; Joseph, J.; Dhanaraj, C. Justin

doi:10.1002/aoc.1831

Cited by 25 publications

(16 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the complexes are non electrolytes as shown by the involvement of the acetate group in coordination. This result was confirmed from the chemical analysis of the CH 3 COO − ion not precipitated by addition of FeCl 3 [17]. The molar conductance values of the metal complexes along with elemental analysis data are given in Table 1.…”

Section: Molar Conductancesupporting

confidence: 59%

Quinoxaline based bio-active mixed ligand transition metal complexes: Synthesis, characterization, electrochemical, antimicrobial, DNA binding, cleavage, antioxidant and molecular docking studies

Dhanaraj

Johnson

2015

Journal of Photochemistry and Photobiology B: Biology

Self Cite

View full text Add to dashboard Cite

Section: Molar Conductancesupporting

confidence: 59%

Quinoxaline based bio-active mixed ligand transition metal complexes: Synthesis, characterization, electrochemical, antimicrobial, DNA binding, cleavage, antioxidant and molecular docking studies

Dhanaraj

Johnson

2015

Journal of Photochemistry and Photobiology B: Biology

Self Cite

View full text Add to dashboard Cite

“…The compound 1 shows a band at 3326 cm -1 due to the free NH stretching [20]. The coordination of metal ions with ligand is evidenced by the shift in -NH band towards higher frequency around 35-18 cm -1 .…”

Section: Infrared Spectramentioning

confidence: 99%

Synthesis, spectral characterization, DNA interaction, anticancer and molecular docking studies on some transition metal complexes with bidentate ligand

Dhanaraj¹,

Hassan

Johnson³

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

Self Cite

View full text Add to dashboard Cite

“…Kivelson and Neiman noted that for an ionic environment, g is normally 2.30 or larger but for covalent environment, g is less than 2.30. The g value for all copper complexes was lower than 2.3 (2.178) indicating a covalent environment [8,[53][54][55].…”

Section: Electron Spin Resonance Of Cu(ii) Ni(ii) Co(ii) Mn(ii) Andmentioning

confidence: 85%

“…Since g > g⊥ indicating a tetragonal distortion around the Cu(II) ions corresponding to elongation along the four fold symmetry Z-axis. The trend g > g⊥ > g e (2.0023) shows that the unpaired electron is localized in the d x2-y2 orbital [53][54][55][56]. In addition exchange coupling interaction between two Cu(II) ions is explained by Hathaway expression G = (g −2)/(g − 2).…”

Section: Electron Spin Resonance Of Cu(ii) Ni(ii) Co(ii) Mn(ii) Andmentioning

confidence: 97%

“…In addition exchange coupling interaction between two Cu(II) ions is explained by Hathaway expression G = (g −2)/(g − 2). If G > 4.0, the exchange interaction is negligible but if the G < 4.0, significant exchange coupling interaction between two copper(II) ions is present in solid complexes, which is typically the case for 3 (G = 3.570) [24,[53][54][55][56]. Kivelson and Neiman noted that for an ionic environment, g is normally 2.30 or larger but for covalent environment, g is less than 2.30.…”

Section: Electron Spin Resonance Of Cu(ii) Ni(ii) Co(ii) Mn(ii) Andmentioning

confidence: 99%

See 1 more Smart Citation

Coordination behaviour of N′1,N′4-bis((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methylene) succinohydrazide toward transition metal ions and their antimicrobial activities

Saied

Shakdofa

Tabl

et al. 2014

Main Group Chemistry

View full text Add to dashboard Cite

Complexes of Cu(II), Ni(II), Co(II), Mn(II), Zn(II) and Fe(III) with N 1 ,N 4 -bis((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl)methylene) succinohydrazide are reported and characterized using various analytical and spectroscopic techniques like 1 H NMR-, mass-, IR-, ESR-, UV-Vis. spectra, magnetic moment and molar conductivity measurements as well as elemental and thermal analyses. The ligand behaves as a dibasic hexadentate N 2 O 4 bonded covalency via the enolic carbonyl oxygen of hydrazide moiety and coordeinated via carbonyl oxygen of antipyrine moiety and azomethine nitrogen atoms. Based on magnetic and electronic spectra data a distorted octahedral geometry around the metal ions has been proposed. The ESR spectrum of copper(II) complexes (3) showed axial symmetry with g >g⊥>g e , indicating a distorted octahedral structure and presence of the unpaired electron in d (x2-y2) orbital. The antimicrobial activities results of the metal complexes 2, 3, 4, 5, 8, 11, 13 and 16 show that, all these complexes exhibit moderate to mild inhibitory effects aganist Bacillus subtilis, Escherichia Coli and Aspergillus niger while the parent ligand is inactive. This enhancement may be attrubied to their structures which possess an additional C=N bond. Moreover, coordination reduces the polarity of the metal ion mainly because of the partial sharing of its positive charge with the donor atom within the chelate ring system, which formed during the coordination. This process, in turn, increases the lipophilic nature of the central metal atom, which favors its permeation more efficiently through the lipid layer of the microorganism thus destroying them more aggressively.

show abstract

Copper(II) complexes of hydroxyflavone derivatives as potential bioactive molecule to combat antioxidants: synthesis, characterization and pharmacological activities

Cited by 25 publications

References 52 publications

Quinoxaline based bio-active mixed ligand transition metal complexes: Synthesis, characterization, electrochemical, antimicrobial, DNA binding, cleavage, antioxidant and molecular docking studies

Quinoxaline based bio-active mixed ligand transition metal complexes: Synthesis, characterization, electrochemical, antimicrobial, DNA binding, cleavage, antioxidant and molecular docking studies

Synthesis, spectral characterization, DNA interaction, anticancer and molecular docking studies on some transition metal complexes with bidentate ligand

Coordination behaviour of N′1,N′4-bis((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methylene) succinohydrazide toward transition metal ions and their antimicrobial activities

Contact Info

Product

Resources

About