Copper(II) complexes of bidentate mixed ligands as artificial nucleases: Synthesis, crystal structure, characterization and evaluation of biological properties

Jayamani, Arumugam; Bellam, Rajesh; Gopalakrishnan, Gayathri; Ojwach, Stephen O.; Sengottuvelan, Nallathambi

doi:10.1016/j.poly.2018.09.011

Cited by 24 publications

(18 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2). Furthermore, iithe iinew iivibrational iifrequencies was iinoticed iiat ii430-458 iicm −1 iiand ii492-530 iicm −1 region iicorresponds to ii(M-O) iiand ii(M-N), iirespectively [Jayamani A, Bellam R, Gopu G, Ojwach SO and Sengottuvelan N, 2018]. iiIn iiaddition, the iinature coordination iiof iiacetate iiion iito iimetal iiwas iiconfirmed based iion iithe iifrequencies, ii1550-1560 iicm -1 iiand 1310-1368 iicm -1 iiindicates iithe iimonodenate iichelation iiof acetateion.…”

Section: Ir Iistudymentioning

confidence: 89%

“…SOD iiactivity iiof iiprepared iimetal iicomplexes iiwas measured iiusing iiNBT iiassay iimethod iiand iiexpressed IC50 [Jayamani A, Bellam R, Gopu G, Ojwach SO and Sengottuvelan N, 2018].…”

Section: Sod Iiactivitymentioning

confidence: 99%

“…Antituberculosis iiactivity iiof iititle iicomplexes iiwere recorded iiwith iithe iiaid iiof iiMicroplate iiAlamar iiBlue Assay (MABA) ii [Jayamani A, Bellam R, Gopu G, Ojwach SO and Sengottuvelan N, 2018].…”

Section: Antituberculosis Iiactivitymentioning

confidence: 99%

“…The iiefficiency iiof iititle iichelates iiin iivitro antimicrobials iiwere iiscreened iiagainst iimicrobial species [Jayamani A, Bellam R, Gopu G, Ojwach SO and Sengottuvelan N, 2018]. iiThe iiselected iimicroorganisms were iiprogressed iiat iioptimum temperature iiin suspended liquid iibroth iifor ii24 iihrs.…”

Section: Antimicrobial Iiactivitiesmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Jyothi¹,

Vincent²,

Joseph³

2021

alinteri

View full text Add to dashboard Cite

Heterocyclic compounds, in particular oxygen-containing heterocyclic compounds, are of special interest to medicinal chemists because of their unusual biological properties. In the present study, the highly conjugated nitrogen heterocyclic scaffold comprised of flavone derivative with metal acetates to form metal chelates of the type [MIIL(OAc)2], flavone analogues (L); M=Co2+, Zn2+, Cu2+ and Ni2+. The above title compounds were characterized using composition analysis o fCHN and spectroscopic techniques. Based on spectroscopic and analytical measurements confirmed that square planar arrangements for the Co2+, Zn2+, Cu2+ and Ni2+ complexes. Antimicrobial efficacy of prepared complexes were assessed against A.flavus, A.niger, B.subtilis, E. coli, C. albicans and S.aureus. The anti-mycobacterial (H37Rv) efficacy of flavone analogues and its complexes were screened using MABA approach and compared with standard. The acetylcholinesterase (AChE) inhibitory effect of the ligand was examined to find out the therapeutic efficiency of compound in the treatment of neurodegenerative disorders. The synthesized ligand exhibited selective inhibition (AChE & BuChe) values (IC50:0.20(flavone analogue), 2.41 (Rivastigmine) and 3.01 µM (Galantamine), respectively. Further, the in vitro ant-inflammatory efficiency of metal chelates were performed with the help of egg albumin method. The α-glucosidase inhibition activity was also carried out for the prepared metal complexes.

show abstract

Section: Ir Iistudymentioning

confidence: 89%

Section: Sod Iiactivitymentioning

confidence: 99%

Section: Antituberculosis Iiactivitymentioning

confidence: 99%

Section: Antimicrobial Iiactivitiesmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Jyothi¹,

Vincent²,

Joseph³

2021

alinteri

View full text Add to dashboard Cite

show abstract

“…In general, the synthesized metal complexes have higher biological activities compared to the free ligands. The increased inhibition activity of the metal complexes can be explained on the basis of Tweedy's chelation theory 26 . In metal complexes, on chelation the polarity of the metal ion will be reduced to a greater extent due to the overlap of the ligand orbital and partial sharing of the positive charge of the metal ion with donor groups.…”

Section: Absorption Spectral Titrationsmentioning

confidence: 99%

Untitled

2020

IJPSR

View full text Add to dashboard Cite

Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment and electronic spectral data, square planar geometry has been suggested for metal complexes. The binding behavior of the complexes with calf thymus DNA has been investigated by electronic absorption spectra and cyclic voltammetry techniques. The DNA binding constants reveal that all these complexes interact with DNA through intercalation binding mode. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. The antioxidant activities of the complexes showed higher activities. Fluorescent studies reveal that the absorption band is shifted towards visible region indicates that the pyrazoline derivatives of metal complexes may exhibit different emission with respect to suitable substituent present in the pyrazoline structural core. Naphthyl group is responsible for the green colour emission due to its conjugation and electronic delocalization within the molecule and leads to longer wavelength. INTRODUCTION: Metal-containing compounds/ complexes offer many distinct advantages over traditional organic i.e., carbon-based compounds in the development of new medicinal lead molecules due to their capability to coordinate ligands/organic molecules 1-6 .

show abstract

A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

Bhattacherjee

Roy

Naskar

et al. 2021

Applied Organom Chemis

View full text Add to dashboard Cite

A trinuclear copper complex [Cu 3 (napxshz) 2 (phen) 2 ] has been synthesised using a tribasic naproxen-appended ligand [propanoyl) benzohydrazide] and 1,10-phenanthroline. The complex was characterised by different spectroscopic methods such as Fouriertransform infrared (FT-IR), ultraviolet-visible (UV-Vis) and electrospray ionisation (ESI)-mass spectroscopy. The solid-state structure of the ligand and complex 1 was established by single-crystal X-ray diffraction analysis. The interaction of the complex and the ligand with DNA was investigated by UV-visible spectroscopy and fluorometric titrations. The calculated binding constants (K b ) of the complex and the ligand with ct-DNA show that the complex has a higher binding affinity than the ligand H 3 napxshz. Quantum chemical calculations were performed to understand the structural aspects of the complex and its interactions with DNA. The molecular docking study reveals the interaction between DNA, and the complex is in intercalative mode.

show abstract

Copper(II) complexes of bidentate mixed ligands as artificial nucleases: Synthesis, crystal structure, characterization and evaluation of biological properties

Cited by 24 publications

References 80 publications

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Untitled

A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

Contact Info

Product

Resources

About