Copper(II) and zinc(II) complexes bridged by benzenoid aromatic oxocarbon and dicarboxylate dianions

Mautner, Franz A.; Fischer, Roland; Torvisco, Ana; Grant, Emeralde P.; Romain, Destiny S. St.; Salem, Nahed M.H.; Louka, Febee R.; Massoud, Salah S.

doi:10.1016/j.poly.2023.116327

“…The donor atoms are C, N, O, S, or P that form tetrahedron, pentahedron, and hexahedron geometries in cysteine, glutamate, aspartate, and histidine [70,116]. If the donor atom is a water donor molecules, there are tetrahedral, pyramidal, and octahedral coordination geometries [117]. According to Zn's hard acid nature, the donor atoms O or N are coordinated in the first row rather than S or P in the second row [118].…”

Section: Copper and Zinc In Chelating Structuresmentioning

confidence: 99%

“…Copper and zinc ions are endogenously non-toxic transition-metal cations [127]. The common organic ligands are benzene 1,3,5-tricarboxylate (BTC) and tetrakis (4-carboxyphenyl) porphyrin (TCPP) for copper and zeolitic imidazolate (ZIF) for zinc [117]. ZIF may have different formations of ZIF-74 and ZIF-8 and coatings of alginate (Alg) and hyaluronic acid (HA) for different drugs like ibuprofen [128], metformin [129], and tetracycline [130].…”

Section: Copper and Zinc Ions In Metal-organic Framework Structuresmentioning

confidence: 99%

“…The relationship between their formation structures and derivatives is described in Figure 2. For instance, the imidazole and pyridine groups [138] have their derivatives of imidazolate, diimine, benzimidazole, and Ambaf; and bipyridine, terpyridine, and Apyepy, respectively [117]. Both groups are combined to form a derivative of 4-butyloxy-2,6-bis(1-methyl-2-benzimidazolyl) pyridine.…”

Section: Copper Zinc and Cuzn In Organic Solvent Formation Structuresmentioning

confidence: 99%

See 1 more Smart Citation

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…The donor atoms are C, N, O, S, or P that form tetrahedron, pentahedron, and hexahedron geometries in cysteine, glutamate, aspartate, and histidine [ 67 , 111 ]. If the donor atom is a water donor molecule, there are tetrahedral, pyramidal, and octahedral coordination geometries [ 112 ]. According to Zn’s hard acid nature, the donor atoms O or N are coordinated in the first row rather than S or P in the second row [ 113 ].…”

Section: Copper Zinc and Cuzn Structures In Anti-chemoresistancementioning

confidence: 99%

“…Copper and zinc ions are endogenously non-toxic transition-metal cations [ 124 ]. The common organic ligands are benzene 1,3,5-tricarboxylate (BTC) and tetrakis (4-carboxyphenyl) porphyrin (TCPP) for copper and zeolitic imidazolate (ZIF) for zinc [ 112 ]. ZIF may have different formations of ZIF-74 and ZIF-8 and coatings of alginate (Alg) and hyaluronic acid (HA) for different drugs such as ibuprofen [ 125 , 126 ], metformin [ 127 , 128 ], and tetracycline [ 127 , 128 ].…”

Section: Copper Zinc and Cuzn Structures In Anti-chemoresistancementioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi

¹

,

Miskon

²

2023

Molecules

16

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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Structural Diversity and Dimensionality of Three Cu(II)-dpds-C₅O₅^2– Coordination Polymers Controlled by the Coordination Sphere of Cu(II) Centers and the Coordination Modes of C₅O₅^2– (dpds = 4,4′-Dipyridyldisulfide)

Wang,

Liao,

Chung

et al. 2024

ACS Omega

0

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Cu 2 (dpds) 2 (C 5 O 5 ) 2 (H 2 O) 4 ]•3H 2 O (1), [Cu(dpds)(C 5 O 5 )]•3H 2 O (2), and [Cu 2 (dpds) 2 (C 5 O 5 ) 2 ]•9H 2 O•C 2 H 5 OH (3) (dpds = 4,4′-dipyridyldisulfide and C 5 O 5 2− (croconate) = dianion of 4,5-dihydroxycyclopent-4ene-1,2,3-trione), have been synthesized and structurally characterized. Compound 1 contains two crystallographically independent Cu(II) ions, which are both distorted octahedral geometry with elongation along the croconate-and H 2 O-bound axial positions and bonded with two N atoms of two dpds, two O atoms of one C 5 O 5 2−, and two H 2 O molecules. Two crystallographically independent dpds ligands, both adopting the bismonodentate bridging mode, connect two Cu(II) ions to form a onedimensional zigzag chain-like coordination polymer. In 2 and 3, there are two and three crystallographically independent Cu(II) ions, respectively, which are all distorted octahedral geometries with elongation along the croconate-bound axial positions six-coordinated and bonded with two N atoms of two dpds ligands in cis-or/and trans-forms and four O atoms of two C 5 O 5 2− ligands. The dpds ligands in 2 and 3 all adopt the bis-monodentate bridging mode, and the C 5 O 5 2− ligands act as bridging ligands with bridging bis-bidentate through three C 5 O 5 2− oxygen atoms in 2 and bridging bis-bidentate through four adjacent C 5 O 5 2− oxygen atoms in 3, respectively, linking the Cu(II) ions to generate a two-dimensional layered and a three-dimensional metal−organic framework, respectively. The structural diversity and dimensionality observed in 1−3 may be attributed to the cis-or/and trans-coordination sphere of Cu(II) centers with two dpds ligands and the coordination modes of croconate ligands. Thermal stability and in situ temperature-dependent structural variations of 1−3 have been verified by thermogravimetric analysis and powder X-ray diffraction measurements. Compounds 1 and 3 both exhibit water vapor capture behaviors with hysteresis isotherms.

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Copper(II) and zinc(II) complexes bridged by benzenoid aromatic oxocarbon and dicarboxylate dianions

Cited by 4 publications

References 93 publications

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Structural Diversity and Dimensionality of Three Cu(II)-dpds-C₅O₅^2– Coordination Polymers Controlled by the Coordination Sphere of Cu(II) Centers and the Coordination Modes of C₅O₅^2– (dpds = 4,4′-Dipyridyldisulfide)

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Copper(II) and zinc(II) complexes bridged by benzenoid aromatic oxocarbon and dicarboxylate dianions

Cited by 4 publications

References 93 publications

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Structural Diversity and Dimensionality of Three Cu(II)-dpds-C5O52– Coordination Polymers Controlled by the Coordination Sphere of Cu(II) Centers and the Coordination Modes of C5O52– (dpds = 4,4′-Dipyridyldisulfide)

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Structural Diversity and Dimensionality of Three Cu(II)-dpds-C₅O₅^2– Coordination Polymers Controlled by the Coordination Sphere of Cu(II) Centers and the Coordination Modes of C₅O₅^2– (dpds = 4,4′-Dipyridyldisulfide)