Copper(I) tetrahydroborate derivatives containing phosphine and phenanthroline ligands: an electrospray mass spectrometric study of species in solution

Colton, R.; James, B. D.; Potter, Ian D.; Traeger, John C.

doi:10.1021/ic00064a009

Cited by 76 publications

(24 citation statements)

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“…Positive and negative ion electrospray mass spectra were recorded by using DMF as a solvent in order to identify products and intermediates in the rearrangement reactions of A and B into C. Such analysis is possible since the ESMS technique enables transfer of preexisting ions from solution into the gas phase [25]. All electrospray mass spectra measurements were made with freshly prepared solutions as well as with the solutions that were left to stand for several hours having initial concentrations close to 10 (4 and 10 (5 mol dm (3 .…”

Section: Mass Spectramentioning

confidence: 99%

Synthesis and characterisation of Pd(II) complexes with a derivative of aminoazobenzene

Ćurić

Babić

Marinić

et al. 2003

Journal of Organometallic Chemistry

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Section: Mass Spectramentioning

confidence: 99%

Synthesis and characterisation of Pd(II) complexes with a derivative of aminoazobenzene

Ćurić

Babić

Marinić

et al. 2003

Journal of Organometallic Chemistry

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“…A wide range of samples have been ionized, including protein^,^ carbohydrate^,^ nu~leotides,~ and inorganic complexes. 6 Relatively few studies, however, have focused on the gas-phase reaction chemistry of ions generated by electrospray. A great potential exists for using ion/molecule reactions to obtain structural and thermodynamic information about multiply charged ions.…”

mentioning

confidence: 99%

Deprotonation reactions of multiply protonated ubiquitin ions

Cassady

Wronka

Kruppa

et al. 1994

Rapid Comm Mass Spectrometry

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The gas-phase deprotonation reactions of multiply protonated ubiquitin ions have been studied in a Fourier-transform ion cyclotron resonance mass spectrometer. Electrospray ionization was used to generate ubiquitin ions with attachment of 7-13 protons. Rate constants were measured for the reactions of these protein ions with four amines: n-propylamine, di-n-propylamine, tri-n-propylamine, and N,N,N',N'-tetramethyl-1,4-diaminobutane. The gas-phase basicities of the amines ranged from 210.1 kcal/mol to 232.6 kcal/mol. The rate constants were found to increase as the charge state of the ion increased and as the basicity of the amine increased. Several reactions proceed at near the collision rate and have rate constants in excess of 10(-8) cm3 molecule-1 s-1. With the more basic reactants, multiple protons could be stripped sequentially from ubiquitin ions at roughly equivalent rates, suggesting that these protons are attached to sites with similar basicities. In general, deprotonation occurs if the gas-phase basicity of the amine is within 10 kcal/mol of the intrinsic gas-phase basicity of the amino acid residue being deprotonated. For [M+nH]n+, n = 4-6, nonlinear pseudo-first-order kinetic behavior indicated the presence of multiple ion structures. Kinetic, structural and thermodynamic aspects of these reactions are discussed.

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“…Previous studies had shown that for almost every case where the identity of ions in solution was established by some techniques other than MS such as NMR spectroscopy or electrochemistry, the intact ions observed by ESI-MS agreed with the prior identification [203,207]. Also, because ESI-MS is capable of detecting all ionic components of a rapidly exchanging labile system [209,210], it provides a good alternative to low-temperature NMR studies. Thus, isolated ions are available for structural analysis by tandem mass spectrometry using techniques such as CID, providing information about organometallic complex stoichiometries.…”

Section: Mechanism Elucidation Of Organometallic Reactionsmentioning

confidence: 76%

Historical Perspectives in the Study of Ion Chemistry by Mass Spectrometry: From the Gas Phase to Solution

Chen

2009

Reactive Intermediates

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Mass spectrometry (MS), originally developing from nineteenth-century physics, has a history dating back more than a hundred years. Since then, the technique has advanced enormously. The advent of new methods of ion production, novel mass analyzers, and new tools for data processing has made it possible to analyze almost all chemical entities, ranging from small organic compounds to large biological molecules and whole living cells/tissues. Today, mass spectrometry has become one of the most powerful and popular modern physical-chemical methods to study the details of elemental and molecular processes in nature. Because of its unparalleled capability of providing information on molecular weight, chemical structures, isotopic content, and even molecular dynamics, mass spectrometry is playing an increasingly significant role in the chemical and life sciences. As a traditional analytical tool and a booming technology for biomedicine, it has found extensive applications in nearly every discipline involving chemical analysis such as petroleum prospecting and refining, food processing, drug discovery, metablomics, genomics, proteomics and structural biology, as well as the environment, public safety, and industrial process monitoring. Along with the development of mass spectrometric technology, the chemistry of gaseous ions has been explored by the study of unimolecular and collision-induced dissociation (CID) [1][2][3][4] and by the study of ion/molecule reactions [2,[5][6][7][8][9][10][11][12][13][14][15][16][17] and ion/ion reactions [18][19][20][21][22][23][24][25][26] in the gas phase. The study of gas-phase ion chemistry has both fundamental and practical significance because it not only provides diverse information on ion reactivity, thermochemistry, and dynamics, but it also forms one basis for chemical analysis using mass spectrometry. In addition, the ion reactivity examined in the isolated gas-phase environment of mass spectrometers has a strong connection with reaction chemistry in solution, as well as contrasting with it. Many important ionic intermediates which are hard to probe in the condensed phase can be easily accessed in the gas phase. Therefore, mass spectrometry has also become an important and unique tool for the mechanistic investigation of organic reactions (particularly organometallic reactions), since soft electrospray ionization (ESI) technology [27, 28] became available. In this regard, there is a large body of work in the literature, which is reviewed in this book. j37This chapter will provide an overview of the history and the current state of the art of mass spectrometry-based study of ion chemistry, specifically of ion/molecule reactions. As this is a broad topic with an immense literature (over 15 000 papers), our emphasis will be placed on the applications of ESI-MS coupled with gas-phase ion/ molecule reactions and tandem mass spectrometry in organometallic chemistry, including probing key intermediates and reaction pathways of organometallic reactions in solution. We will start with...

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Copper(I) tetrahydroborate derivatives containing phosphine and phenanthroline ligands: an electrospray mass spectrometric study of species in solution

Cited by 76 publications

References 1 publication

Synthesis and characterisation of Pd(II) complexes with a derivative of aminoazobenzene

Synthesis and characterisation of Pd(II) complexes with a derivative of aminoazobenzene

Deprotonation reactions of multiply protonated ubiquitin ions

Historical Perspectives in the Study of Ion Chemistry by Mass Spectrometry: From the Gas Phase to Solution

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