Copper(I) complexes with bidentate tertiary phosphine ligands: solution chemistry and antitumor activity

Abstract

the geometry of the exchange pathways, the electronic structure and anisotropy of the M and X species, and the overlap of the different metal d orbitals with those on the X04 group. Clearly, these will be very sensitive to different M and X atoms, which accounts for the variety of magnetic structures seen in these compounds and the difficulty in rationalizing them.Acknowledgment. The authors thank R. S. McLean for collecting the susceptibility data, M. W. Sweeten for technical as-sistance, and the SERC for the provision of neutron facilities and a studentship for J.P.A.

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase

“…Auranofin was shown to possess in vivo antitumor activity against P388 murine leukemia and in vitro cytotoxic potency against both B16 melanoma and P388 leukemia cells for two decades [8]. However, very recently, additional in vitro studies indicated that auranofin is able to overcome cisplatin resistance in human 4 ovarian cancer cells [9], confirming the earlier assumption that a mechanism of action different from the recognized DNA damage induced by cisplatin could underlie the cytotoxic activity of phosphine Au(I) drugs.…”

The first bis(phosphine) monoxide (BPMO) complexes of copper(I)

“…The lability of copper(I) complexes in solution is well known [17]. In order to examine the solution behavior of these complexes, the 31 P NMR spectra were recorded for the complexes and the free ligand.…”

Asymmetric catalytic addition of diorganozinc reagents to imines: Scope and application

“…8)? Such phosphine oxidation is well precedented with palladium chemistry [12c,21], and it has also been reported for copper sulfate and dppe [22].…”