Copper-Hydroxo Chelates of Clofibric Acid (CA): Reaction of Cu2+ with CA

Abstract

2-(p-Chlorophenoxy)-2-Methylpropionic acid or (Clofibric acid (CA) chemical formula C 10 H 11 ClO 3 ) is a ligand that binds to Peroxisome proliferator-activated receptorsalpha (PPARα). This ligand has two centers of attachments that can chelate a variety of metal ions. From our ongoing efforts to study the reaction of CA with many metal ions such as Al 3+ , Zn 2+ , Cr 3+ and Fe 3+ , we are reporting the outcome of the reactions of CA with the hexa-aqua Cu 2+ ion in aqueous solutions under ambient conditions using well established techniques. The main techniques used were potentiometry, UV-Vis, and IR spectroscopies. It appeared that the major species formed from the reaction of CA with Cu 2+ is the ternary [Cu 2+ (CA) (OH) 2 ]species. These studies are novel and shed light on this reaction system. UV-Vis spectra of CA, and CA-Cu 2+ complexes are novel. IR spectroscopy proved the participation of the hydroxylate group of CA in the chelation of the Cu 2+ ion.