Copper-guided tuning of supramolecular nano-assembly in pseudopeptide-based soft bioinspired materials

Abstract

Pseudopeptide-based soft bioinspired materials are recently emerging state-of-the-art soft matter for recognition and supramolecular self-assembly. Therefore, we find L-valine and L-phenylalanine-based C2-symmetric pseudo-peptidic soft bioinspired materials for selective and sensitive...

Design of C2-symmetric pseudopeptides for in vivo detection of Cu(ii) through controlled supramolecular nano-assembly

“…42 Our recent research has highlighted the emergence of bio-inspired pseudopeptides as cutting-edge soft materials, demonstrating impressive capabilities in recognizing various metal ions and supramolecular self-assembly. 43,44 Here, we report a new class of chiral pseudopeptide-based probes (2S,2′S)-N,N'-(1,3-phenylenebis(methylene))bis(2-(((E)-4-(diethylamino)-2-hydroxybenzylidene)amino)-3-methylbutanamide) (4) and (2S,2′S)-N,N′-(1,3-phenylenebis(methylene))bis(2-(((Z)-4-(diethylamino)-2-hydroxybenzylidene)amino)-3-phenylpropanamide) (5) 45 containing m-xylylenediamine as an aromatic linker between two amino acid units (Scheme 1). 4 exhibits selective detection of Cu(II) ions through the inhibition of the ESIPT mechanism.…”