Copper-Gallic Acid Nanoscale Metal–Organic Framework for Combined Drug Delivery and Photodynamic Therapy

Sharma, Shalini; Mittal, Disha; Verma, Anita; Roy, Indrajit

doi:10.1021/acsabm.9b00116

Cited by 49 publications

(38 citation statements)

References 45 publications

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“…A hysteresis loop was observed at P/P 0 = 0.5, and the curve is a type IV isotherm curve which indicates that CuGA 90-2.2 has a mesoporous structure with an H3 hysteresis loop caused by a delay of the desorption process [27][28][29] . The calculated BET surface area, total pore volume, and average pore diameter of CuGA 90-2.2 are 198.22 m 2 /g, 0.4262 cc/g, and 8.6 nm, respectively which are comparable to the CuGA NMOF reported by Sharma et al (172 m 2 /g, 0.73 cc/g, and 2.2 nm, respectively) 19 . These results suggest that the newly developed synthetic method at relatively low temperature (90 °C) and in the absence of solvents can be used to produce CuGA MOF with similar characteristics as the DMF-synthesized CuGA NMOF.…”

Section: Effect Of Naoh To Ga Molar Ratio On the Characteristics Of Csupporting

confidence: 79%

“…The first set of reactions were done by varying X with temperature fixed at 60 °C. The purpose was to determine the proper amount of NaOH required to produce CuGA MOF with comparable characteristics to that of the reference material, CuGA NMOF 19 . Product yield and XRD pattern were employed as the basis for this screening.…”

Section: Effect Of Naoh To Ga Molar Ratio On the Characteristics Of Cmentioning

confidence: 99%

“…NaOH has a modulatory role in promoting the coordination between Cu and GA. As a base, NaOH triggers the deprotonation of carboxylic acid and hydroxyl group of GA, thus produces electron-rich GA. This negatively-charged GA then provides better attraction towards the surrounding metal ions and facilitates interaction of Cu and GA 19 . At a lower NaOH concentration (X = 1.1), there was only a limited amount of OH − ions available for GA deprotonation.…”

Section: Effect Of Naoh To Ga Molar Ratio On the Characteristics Of Cmentioning

confidence: 99%

“…To date, the applicability of CuGA MOF is inferior to other extensively studied MOFs such as MIL-100, MIL-101, UiO-66, ZIF-8 18 . While the application of CuGA MOFs as drug carrier with superior antitumor activity has been reported previously 19 , their adsorptive behavior remains elusive. The preparation of CuGA MOF was first introduced by Sharma et al who reacted Cu (II) and GA with a mixture of solvents containing Aerosol OT, n-butanol, and N,N-dimethylformamide (DMF) 19 .…”

mentioning

confidence: 99%

“…While the application of CuGA MOFs as drug carrier with superior antitumor activity has been reported previously 19 , their adsorptive behavior remains elusive. The preparation of CuGA MOF was first introduced by Sharma et al who reacted Cu (II) and GA with a mixture of solvents containing Aerosol OT, n-butanol, and N,N-dimethylformamide (DMF) 19 . However, the use of DMF is not desirable due to its harmful potential to the environment 20 .…”

mentioning

confidence: 99%

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Aqueous synthesis of highly adsorptive copper–gallic acid metal–organic framework

Azhar

Angkawijaya

Santoso

et al. 2020

Sci Rep

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A greener route to synthesize mesoporous copper–gallic acid metal–organic framework (CuGA MOF) than the conventional method using harmful DMF solvent was proposed in this study. Various synthesis attempts were conducted by modifying the synthesis conditions to produce CuGA MOF with comparable physical properties to a reference material (DMF-synthesized CuGA NMOF). The independent variables investigated include the molar ratio of NaOH to GA (1.1 to 4.4) and the synthesis temperature (30, 60, 90 °C). It was found that proper NaOH addition was crucial for suppressing the generation of copper oxide while maximizing the formation of CuGA MOF. On the other hand, the reaction temperature mainly affected the stability and adsorption potential of CuGA MOF. Reacting Cu, GA, and NaOH at a molar ratio of 1:1:2.2 and a temperature of 90 °C, produced mesoporous MOF (CuGA 90–2.2) with a surface area of 198.22 m2/g, a pore diameter of 8.6 nm, and a thermal stability of 219 °C. This MOF exhibited an excellent adsorption capacity for the removal of methylene blue (124.64 mg/g) and congo red (344.54 mg/g). The potential usage of CuGA 90–2.2 as a reusable adsorbent was demonstrated by its high adsorption efficiency (> 90%) after 5 adsorption–desorption cycles.

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Section: Effect Of Naoh To Ga Molar Ratio On the Characteristics Of Csupporting

confidence: 79%

Section: Effect Of Naoh To Ga Molar Ratio On the Characteristics Of Cmentioning

confidence: 99%

Section: Effect Of Naoh To Ga Molar Ratio On the Characteristics Of Cmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Aqueous synthesis of highly adsorptive copper–gallic acid metal–organic framework

Azhar

Angkawijaya

Santoso

et al. 2020

Sci Rep

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Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Liang

2020

Adv Funct Materials

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Biocatalytic metal-organic framework (MOF) composites, synthesized by interfacing MOFs with biocatalytic components, possess the unprecedented synergetic properties that is hard to achieve by the conventional strategies, represents one of the next-generation composite materials for diverse biotechnological applications. Until now , research on the applications of biocatalytic MOFs is still in its preliminary stage, with a wide variety of studies being focusing on the bioprotection role of MOFs. However, their diversity of building units, molecular-scale tunability, modular synthetic routes, and more detailed understanding of the heterogeneous MOF-biointerface could even lead to completely new applications and potentials beyond our current imagination. The most recent rapid advanced progress in biocatalytic MOFs present ground-breaking applications in smart and tunable biocatalysis, precision nanomedicine, vaccine and gene delivery, biosensing and nano-biohybrids. Herein, the general and advanced synthesis strategies for improving the materials properties of biocatalytic MOFs, from tuning biocatalytic activity to framework stability to synergistic properties with other materials, are summarized. Then, the latest state-of-the-art applications of the biocatalytic MOF systems and recent advanced developments that are shaping this emerging field are surveyed. Finally, to define promising research directions, a critical evaluation and future prospects for the potential applications of biocatalytic MOFs are provided.

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Redox Homeostasis Disruptors Based on Metal‐Phenolic Network Nanoparticles for Chemo/Chemodynamic Synergistic Tumor Therapy through Activating Apoptosis and Cuproptosis

Zhao,

Yu,

Liang

et al. 2023

Adv Healthcare Materials

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The combination of chemo/chemodynamic therapy is a promising strategy for improving antitumor efficacy. Herein, metal‐phenolic network nanoparticles (NPs) self‐assembled from copper ions and gallic acid (Cu‐GA) are developed to evoke apoptosis and cuproptosis for synergistic chemo/chemodynamic therapy. The Cu‐GA NPs are biodegraded in response to the highly expressed glutathione (GSH) in tumor cells, resulting in the simultaneous release of Cu+ and GA. The intracellular GSH content is dramatically reduced by the released GA, rendering the tumor cells incapable of scavenging reactive oxygen species (ROS) and more susceptible to cuproptosis. Meanwhile, ROS levels within the tumor cells are significantly increased by the Fenton‐like reaction of released Cu+, which disrupts redox homeostasis and achieves apoptosis‐related chemodynamic therapy. Moreover, massive accumulation of Cu+ in the tumor cells further induces aggregation of lipoylated dihydrolipoamide S‐acetyltransferase and downregulation of iron‐sulfur cluster protein, activating cuproptosis to enhance the antitumor efficacy of Cu‐GA NPs. The experiments in vivo further demonstrate that Cu‐GA NPs exhibited the excellent biosafety and superior antitumor capacity, which can efficiently inhibit the growth of tumors due to the activation by the tumor specific GSH and hydrogen peroxide. These Cu‐based metal‐phenolic network NPs provide a potential strategy to build up efficient and safe cancer therapy.

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Copper-Gallic Acid Nanoscale Metal–Organic Framework for Combined Drug Delivery and Photodynamic Therapy

Cited by 49 publications

References 45 publications

Aqueous synthesis of highly adsorptive copper–gallic acid metal–organic framework

Aqueous synthesis of highly adsorptive copper–gallic acid metal–organic framework

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Redox Homeostasis Disruptors Based on Metal‐Phenolic Network Nanoparticles for Chemo/Chemodynamic Synergistic Tumor Therapy through Activating Apoptosis and Cuproptosis

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