Copper deficiency myeloneuropathy with a history of malabsorption: a tale of two cases

Qureshi, Anum; Bergbower, Emily Anne Smith; Patel, Janki

doi:10.1080/20009666.2020.1850989

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…The exact prevalence of copper deficiency in active CeD is unclear, but conditions associated with malabsorption of macronutrients and gastrointestinal disease can impair copper uptake and contribute to suboptimal copper status. This deficiency can lead to anemia, thrombocytopenia, neutropenia, peripheral neuronal involvement, and myelopathy [206][207][208][209][210][211]. Disorders that affect the mucosal cells responsible for iron absorption, such as celiac disease, atrophic gastritis, Helicobacter pylori infection, and bariatric surgery, proton pump inhibitors 1…”

Section: Other Micronutrient Deficienciesmentioning

confidence: 99%

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Small and Large Intestine (I): Malabsorption of Nutrients

2021

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Numerous disorders can alter the physiological mechanisms that guarantee proper digestion and absorption of nutrients (macro- and micronutrients), leading to a wide variety of symptoms and nutritional consequences. Malabsorption can be caused by many diseases of the small intestine, as well as by diseases of the pancreas, liver, biliary tract, and stomach. This article provides an overview of pathophysiologic mechanisms that lead to symptoms or complications of maldigestion (defined as the defective intraluminal hydrolysis of nutrients) or malabsorption (defined as defective mucosal absorption), as well as its clinical consequences, including both gastrointestinal symptoms and extraintestinal manifestations and/or laboratory abnormalities. The normal uptake of nutrients, vitamins, and minerals by the gastrointestinal tract (GI) requires several steps, each of which can be compromised in disease. This article will first describe the mechanisms that lead to poor assimilation of nutrients, and secondly discuss the symptoms and nutritional consequences of each specific disorder. The clinician must be aware that many malabsorptive disorders are manifested by subtle disorders, even without gastrointestinal symptoms (for example, anemia, osteoporosis, or infertility in celiac disease), so the index of suspicion must be high to recognize the underlying diseases in time.

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Section: Other Micronutrient Deficienciesmentioning

confidence: 99%

“…Causes and nutritional consequences of malabsorption (main minerals and trace elements)[207][208][209][210][211][212][213][214][215].…”

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confidence: 99%

Small and Large Intestine (I): Malabsorption of Nutrients

2021

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“…Copper deficiency-related myelopathy is similar to subacute combined degeneration of the spinal cord caused by vitamin B12 deficiency, leading to dorsal column deficits in cervical and/or thoracic cord. 12 MRI spine often shows increased T2 signals involving the dorsal column, and electrophysiological studies often indicate sensorimotor axonal polyneuropathy. 13 This is consistent with our study, seven patients (77.8%) had MRI findings which showed posterior column T2 hyperintensities, while most patients (70%) had abnormal nerve conduction studies.…”

Section: Discussionmentioning

confidence: 99%

A case report and literature review of iatrogenic copper deficiency myeloneuropathy due to zinc treatment in patients with Wilson’s disease

Pawa,

Ang,

Chiew

2023

Proceedings of Singapore Healthcare

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Iatrogenic copper deficiency is rare in patients with Wilson’s disease. We present a case of iatrogenic copper deficiency myeloneuropathy secondary to zinc treatment for Wilson’s disease and compare the patient’s clinical features with existing cases. Our study highlights the importance of recognizing subtle clinical manifestations and counselling patients receiving copper-reducing treatment to watch for symptoms of myeloneuropathy. Early biochemical testing, including serum copper, caeruloplasmin and zinc levels, as well as magnetic resonance imaging of the spine and electrophysiological studies, may be helpful in diagnosing copper deficiency-related myeloneuropathy due to zinc treatment. Early detection and treatment of copper deficiency may lead to good recovery of neurological symptoms.

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“…Nutritional deficiencies related to the abovementioned causes include different vitamin or element deficiencies. It is worth mentioning that copper deficiency is rare to come across [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

A Case Series of Patients With Polyneuropathy Due to Copper Deficiency

Gasimova¹,

Jayanth²,

Kafaie³

2023

Cureus

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We are presenting six cases of patients with peripheral polyneuropathy due to malnutrition in settings of prior history of gastric bypass surgery, zinc-based dentures usage, or long-standing alcohol abuse. The clinical presentation in all six patients included sensory, motor, or combined peripheral polyneuropathy and gait instability due to imbalance. All patients included in this case series were found to have low copper levels. Electromyography (EMG) with nerve conduction study (NCS) showed predominantly axonal and length dependent sensory or sensory-motor polyneuropathies. Patients were treated with copper supplements with reportable improvement in their presenting symptoms.

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Copper deficiency myeloneuropathy with a history of malabsorption: a tale of two cases

Cited by 7 publications

References 9 publications

Small and Large Intestine (I): Malabsorption of Nutrients

Small and Large Intestine (I): Malabsorption of Nutrients

A case report and literature review of iatrogenic copper deficiency myeloneuropathy due to zinc treatment in patients with Wilson’s disease

A Case Series of Patients With Polyneuropathy Due to Copper Deficiency

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