Copper concentration in erythrocytes, platelets, plasma, serum and urine: influence of physical training

Abstract

Background Physical training produces changes in the extracellular and intracellular concentrations of trace minerals elements. To our knowledge, only three compartments have been studied simultaneously. The aim of the present study was to analyze the influence of physical training on extracellular (serum, plasma and urine) and intracellular (erythrocytes and platelets) concentrations of Copper (Cu). Methods Forty young men participated in this study. The participants were divided into a training group (TG; n = 20; 18.15 ± 0.27 years; 68.59 ± 4.18 kg; 1.76 ± 0.04 m) and a control group (CG; n = 20; 19.25 ± 0.39 years; 73.45 ± 9.04 kg; 1.79 ± 0.06 m). The TG was formed by semi-professional soccer players from a youth category with a regular training plan of 10 h/week. All of them had been participating in high level competitions and had trained for at least 5 years. Plasma, serum, urine, erythrocyte and platelet samples of Cu were obtained and analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Results The TG showed lower concentrations of Cu in erythrocytes (p < 0.05) despite similar intakes. There were no significant differences in Cu concentrations in plasma, serum, urine and platelets although the trend was similar to that observed in erythrocytes. Conclusions The assessment of trace element concentrations should be carried out in both extracellular and intracellular compartments to obtain a proper evaluation and to identify possible deficiencies of the element. We believe that additional Cu supplementation is needed in athletes who perform physical training regularly.

Evaluation of Trace Element and Heavy Metal Levels of Some Ethnobotanically Important Medicinal Plants Used as Remedies in Southern Turkey in Terms of Human Health Risk

“…Cu plays a key role in metabolic activities such as bone mineralization, brain development, immune system, energy metabolism, maintenance of hematopoietic activity, growth, maturation of red and white blood cells, and Fe transport and metabolism [ 146 ]. Deficiency of Cu can lead to many health problems such as retarded growth and bone abnormalities, anemia, leukopenia, and gray hair [ 147 ].…”

Extracellular and Intracellular Concentrations of Molybdenum and Zinc in Soccer Players: Sex Differences

“…TMEs play important roles in various metabolic functions of the body [ 2 ]. The regulation of TMEs in blood and tissues is important for these functions both at rest and during physical exercise [ 3 ], and it is known that physical exercise can cause a redistribution of TMEs among body stores, blood, and tissues [ 4 ]. In addition, TME status can affect performance in athletes [ 5 , 6 ].…”

“…However, it does not seem to be a specific indicator of Zn status in athletes or the general population [ 19 , 20 ], with no information available for Mo. In view of the above, previous authors proposed simultaneously assessing TME status in different compartments [ 4 , 13 ].…”

Development of a Novel Benzimidazole-Based Probe and Portable Fluorimeter for the Detection of Cysteine in Human Urine

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