Copper-catalyzed α-selective cross-dehydrogenative coupling of BODIPY dyes with aldehydes: A new route to acylated BODIPYs and dipyrromethenes

Copper‐Catalyzed C(sp2)−C(sp2) Bond Formation via Single C(sp2)−H Activation

“…In the late 2022, Hao and co‐workers [48] developed a method for direct acylation of important bioimaging dye, boron dipyrromethene (BODIPY). They used tert ‐butyl hydroperoxide (TBHP) as a radical initiator to form acyl radical from aryl/alkyl aldehydes.…”

Enabling Regioselective Synthesis of α‐Methyl BODIPYs via H2O2/DMSO‐Promoted Direct Methylation

“…To address this issue, radical process [10b,16] might be adaptable to achieve the α ‐methylation, which has been employed in the installation of functional groups to the α ‐position of BODIPY cores, like acylation, [16f] amination [16d] et al. Methylation involving a methyl radical process has also been well established during these years [17] .…”