Copper‐Catalyzed α‐Arylation of Nitroalkanes with (Hetero)aryl Bromides/Iodides
Jianqiang Huang,
Taian Li,
Xiaobiao Lu
et al.
Abstract:α‐Aryl substituted nitroalkanes are valuable synthetic building blocks that can be easily converted into a‐aryl substituted aldehydes, ketones, carboxylic acids, as well as amines. Herein, an efficient Cu/oxalamide‐catalyzed coupling between nitroalkanes and (hetero)aryl halides (Br, I) was developed to direct access highly diverse α‐aryl substituted nitroalkanes. Compared with the current state of art, this protocol is more environmentally friendly and practical for synthetic chemists. This approach is charac… Show more
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