Copper catalyzed reaction of alcohols, alkyl halides and Na₂S₂O₃: an odorless and ligand-free route to unsymmetrical thioether synthesis

Abstract

A CuI-catalyzed condensation reaction between alcohols, alkyl halides, and Na2S2O3 leading to structurally diverse thioethers is reported. A variety of alkyl halides and electron-rich benzyl alcohols were employed successfully in...

Synthesis of α-aryl sulfides by deaminative coupling of α-amino compounds with thiophenols

“…Another key method for the preparation of aryl sulfides is the nucleophilic substitution of sulfides with alcohols, which is mild and efficient, and unsymmetric thioethers can be obtained. 7 In addition, some photocatalytic C–H and C–C functionalization methods are also used in the preparation of thioethers. 8 However, these methods have strict requirements in terms of the steric and electronic properties of substrates, which limits the extension of these strategies.…”