Copper‐Catalyzed One‐Pot Synthesis of 1,3,4‐Oxadiazol‐2(3H)‐ones using DMF as the Carbonyl Source
Ping Jiang,
Qin Su,
Keyume Ablajan
et al.
Abstract:A series of 1,3,4‐oxadiazol‐2(3H)‐ones were prepared by an efficient copper‐catalyzed one‐pot reaction of arylhydrazides, arylboronic acids and DMF. Moderate to good yield of 1,3,4‐oxadiazol‐2(3H)‐ones were obtained using DMF as the carbonyl source and arylboronic as the aryl source. This reaction involved ligand exchange and transmetalation of copper catalysts with arylhydrazides and arylboric acids, followed by reductive elimination and intramolecular cyclization. Compared to the previous work, this work emp… Show more
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