Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles

Hartwig, Daniela; Alves, Diego; Jacob, Raquel G.; Xavier, Maurício Carpe Diem Ferreira

doi:10.2174/157017941206150828114009

Cited by 10 publications

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“…In 2015, Alves and co-workers described a one-pot, two-step reaction sequence comprised of cyclocondensation and Cu( i )-catalysed direct sulfanylation for the synthesis of 4-(arylsulfanyl)-1 H -pyrazoles ( 61 ) (Scheme 48). 42 In this study, the authors also developed the multicomponent version of this method; however, they observed higher yields for the one-pot approach in which the arylhydrazines ( 58 ) and 1,3-diketones ( 59 ) were mixed in the first step for the in situ preparation of 1 H -pyrazole derivatives ( 60 ). The second step involved Cu( i )-catalysed direct sulfanylation employing CuI, 2,2′-bipyridine (bpy), and thiols ( 26 ).…”

Section: Transition Metal Catalysed Direct Sulfanylationsmentioning

confidence: 99%

Transition metal catalysed direct sulfanylation of unreactive C–H bonds: an overview of the last two decades

et al. 2022

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Section: Transition Metal Catalysed Direct Sulfanylationsmentioning

confidence: 99%

Transition metal catalysed direct sulfanylation of unreactive C–H bonds: an overview of the last two decades

et al. 2022

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Copper‐Catalyzed Multicomponent Reactions: Synthesis of Fused 1,2,3‐Triazolo‐1,3,6‐triazonines

et al. 2017

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We describe our results on the synthesis of fused 1,2,3‐triazolo‐1,3,6‐triazonines through a copper‐catalyzed multicomponent reaction. The products were obtained in moderate to excellent yields by the reaction of 2‐azidobenzaldehydes, substituted diaminobenzenes and a range of terminal alkynes in the presence of a catalytic amount of copper iodide, with Et3N as base, in DMSO at 100 °C. This method proved to be efficient for the combinatorial synthesis of new medium‐sized N‐heterocyclic rings with potential applications in biological studies.

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Synthesis of Imidazo[1,2‐a]pyridines: C‐H Functionalization in the Direction of C‐S Bond Formation

Ravi

Adimurthy

2017

The Chemical Record

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Imidazo[1,2-a]pyridines play an important role in medicinal chemistry. In spite of very drastic developments on syntheses and functionalization in this area, the use of inexpensive catalysts and mild reaction conditions constitutes an important role in pharmaceutical applications. This account describes our recent efforts on the development of new methods for the synthesis of imidazo[1,2-a]pyridines using readily available starting substrates and catalysts under very mild reaction conditions. In the direction of enhancement of biological activity, we also described the synthesis of functionalized imidazo [1,2-a]pyridine derivatives.

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Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles

Cited by 10 publications

References 0 publications

Transition metal catalysed direct sulfanylation of unreactive C–H bonds: an overview of the last two decades

Transition metal catalysed direct sulfanylation of unreactive C–H bonds: an overview of the last two decades

Copper‐Catalyzed Multicomponent Reactions: Synthesis of Fused 1,2,3‐Triazolo‐1,3,6‐triazonines

Synthesis of Imidazo[1,2‐a]pyridines: C‐H Functionalization in the Direction of C‐S Bond Formation

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