Copper‐Catalyzed One‐Pot Cascade Cyclization for the Synthesis of Isoindolo[2,1‐a]quinoxalines

Abstract

A copper-catalyzed one-pot cascade cyclization of 2-(1-(acetyloxy)propargyl)benzaldehydes with o-phenylenediamines for an access to substituted isoindolo[2,1-a]quinoxalines has been developed. The reaction features readily available starting materials, simple operational procedure, and broad substrate scopes. Under optimal conditions, various isoindolo[2,1-a]quinoxalines were afforded in 41-88% yields.