Copper-catalyzed intermolecular carboesterification of unactivated aliphatic alkenes with α-carbonyl alkyl bromides via a SET process: efficient synthesis of γ-lactones

Abstract

A novel and efficient copper-catalyzed carboesterification of unactivated alkenes with α-carbonyl alkyl bromides for the syn-thesis of γ-lactones derivatives has been developed. With the assistance of a removable bidentate 8-aminoquinoline...

Divergent functionalization of alkenes enabled by photoredox activation of CDFA and α-halo carboxylic acids

“…13–17 Therefore, several classical approaches towards obtaining nonfluorinated γ-lactones and γ-lactams have been employed using esters, acids, and anhydrides in combination with olefins. 18–30 Alongside, hydrofunctionalization of alkenes via hydrogen atom transfer (HAT) catalysis has gained considerable interest in recent years and accelerated the chemical space of hydro alkylated products. 31–34 Merging the distinct structural features of gem -difluoro compounds with these molecules presents an exciting avenue for the design and development of novel drug candidates.…”

Ferrocene catalyzed carbohydroxylation of alkenes using H2O and cycloketone oxime esters

“…The continuous exploration of novel, environmentally friendly methods for the functionalization of readily available olefins remains a prominent area of research in the field of synthetic organic chemistry. Despite the availability of several catalytic approaches for the mono- and difunctionalization of alkenes using transition metals such as nickel, 1 palladium, 2 copper, 3 gold, 4 rhodium, 5 and iron, 6 as catalysts, there is still significant interest in expanding the range of methodologies. Furthermore, the utilization of photoredox and photochemical strategies has also emerged as a promising avenue for achieving olefin functionalization.…”