Copper-Catalyzed Carbonylative Synthesis of β-Boryl Amides via Boroamidation of Alkenes

Enantioselective Radical Carbocyanation of 1,3-Dienes via Photocatalytic Generation of Allylcopper Complexes

“…Moreover, we further expanded the success of this synergetic catalysis system to the more challenging four-component reaction radical carbonylative carbocyanation. Notably, CO would coordinatively saturate the Cu center and/or compete with cyanides and chiral ligands, thus making the chiral Cu catalyst ineffective or making radical carbonylative carbocyanation unordered. − To our delight, preliminary experiments indicated that the four-component reactions with 1,3-diene 1a or 1,3-enyne 8c occurred in an orderly manner, affording chiral allyl ketocyanide 10 and chiral propargyl ketocyanide 11 in moderate yields and high enantioselectivities (Figure b, 10 : 46% yield and 91% ee; 11 : 48% yield and 88% ee).…”

Copper-catalyzed synthesis of cyclopropyl bis(boronates) from aryl olefins and carbon monoxide

“…A possible pathway was proposed based on previous studies 15,16,19 and the experimental results discussed above (Scheme 5). At first, bis(pinacolato)diboron (B 2 pin 2 ) transferred a boryl group to the copper center in the presence of base.…”

Alkyne insertion into Cu–Al bonds and selective functionalization to form copper acyl compounds

“…22,23 Likewise, Fe-bound acyl units can act as structural models of the Fe hydrogenase active site. 24 For copper, however, these unstable species have been proposed as intermediates in Cu-catalysed reactions such as borocarbonylation and amidation, 25 but have not been isolated, due to their propensity to undergo facile rearrangement.…”