“Copper catalyzed azide alkyne cycloaddition” based synthesis and applications of oligo-1, 2, 3-triazoles connected by suitable building blocks and “N-(CH)n-C” linked triazole oligomers

Abstract

A typical 1,2,3-triazoles are important aromatic heterocyclic compounds with three adjacent nitrogen atoms. These "unnatural" heterocycles found applications in pharmaceutical science, material science and chemical biology. Oligo-1,2,3-triazole linked molecules showed interesting applications in the field of DNA binding, selfassembly, surface modification, supramolecular chemistry etc. In this article, oligo-1,2,3-triazoles are broadly classified into two categories: (i) 1,2,3-triazoles are connected through varieties of organic molecules and (ii) triazole units are connected with one another either by N-(CH)n-C linkages or by amide bonds generated from amino acids. Syntheses and properties of some of these oligomers are reviewed in this article.

Synthesis and in vitro Antimicrobial Screening of Benzofuran-3(2H)-one Linked Geminal bis 1,2,3-Triazole Hybrid Derivatives

“…On the other hand, 1,2,3-triazole and its analogues are attractive scaffolds in pharmaceutical chemistry [18][19][20][21] owing to their substantial biological efficacy, which includes antimicrobial [22,23], antituberculor [24,25], antimalarial [26], anticancer [27] and anti-HIV [28] properties. However, geminal-, bis-and tris-triazoles are a relatively rare and neglected group of triazole compounds that have received little attention from researchers [29][30][31][32][33][34][35]. Despite this, their biological functions have not been extensively studied and remain poorly understood.…”