Abstract:A non-noble
Cu-catalyzed transfer aza-benzyl Michael
addition via
the C–C bond cleavage of aza-benzyl alcohols has been disclosed.
The unstrained C(sp3)–C(sp3) bond of
an alcohol was selectively cleaved. This aza-benzyl transfer strategy
provides a selective and environmentally benign approach for the C-alkylation
of α,β-unsaturated carbonyl compounds that employs readily
available alcohols as carbon nucleophiles and is characterized by
a wide range of substrates and good to excellent yields.
An efficient cyclization for the synthesis of 1,2,4,5-tetra-substituted benzenes via copper catalyzed dimerization of γ,δ-unsaturated ketones has been described.
An efficient cyclization for the synthesis of 1,2,4,5-tetra-substituted benzenes via copper catalyzed dimerization of γ,δ-unsaturated ketones has been described.
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