Copper-Catalyzed Asymmetric Hydroamination of Styrenes with 
            piv
          ZPhos as Ligand

Chen, Chengsheng; Wu, Ling; Wang, Yuwen; Wu, Linglin; Zhang, Yongda

doi:10.1055/s-0040-1707346

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…The reaction proceeded smoothly in the presence of the Cu− piv ZPhos catalyst to furnish the desired products in 32−89% yields with 49−94% ee (Scheme 203). 638 The Ir-or Rh-catalyzed asymmetric C−N bond-forming reaction of oxabenzonorbornadienes with secondary amines accompanying ring-opening was reported by Tang, Luo, and co-workers. 639,640 Among several BI-DIME-type ligands screened, a structurally simple ligand shown in Scheme 204 proved to be the most effective for this asymmetric transformation, providing a series of substituted dihydronaphthalenes 183 in high yields and excellent enantioselectivities.…”

Section: C−n Bond-formingmentioning

confidence: 98%

P-Stereogenic Phosphorus Ligands in Asymmetric Catalysis

Imamoto

2024

Chem. Rev.

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Chiral phosphorus ligands play a crucial role in asymmetric catalysis for the efficient synthesis of useful optically active compounds. They are largely categorized into two classes: backbone chirality ligands and P-stereogenic phosphorus ligands. Most of the reported ligands belong to the former class. Privileged ones such as BINAP and DuPhos are frequently employed in a wide range of catalytic asymmetric transformations. In contrast, the latter class of P-stereogenic phosphorus ligands has remained a small family for many years mainly because of their synthetic difficulty. The late 1990s saw the emergence of novel P-stereogenic phosphorus ligands with their superior enantioinduction ability in Rh-catalyzed asymmetric hydrogenation reactions. Since then, numerous P-stereogenic phosphorus ligands have been synthesized and used in catalytic asymmetric reactions. This Review summarizes P-stereogenic phosphorus ligands reported thus far, including their stereochemical and electronic properties that afford high to excellent enantioselectivities. Examples of reactions that use this class of ligands are described together with their applications in the construction of key intermediates for the synthesis of optically active natural products and therapeutic agents. The literature covered dates back to 1968 up until December 2023, centering on studies published in the late 1990s and later years.

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Section: C−n Bond-formingmentioning

confidence: 98%