Copper catalysed cross-dehydrogenative coupling (CDC) reaction of 4-thiazolidinone with terminal alkyne

Cross‐Dehydrogenative Alkynylation: A Powerful Tool for the Synthesis of Internal Alkynes

“…This reaction is the first example of the alkynylation of benzylic C−H bonds that are not adjacent to a nitrogen atom. Through a radical strategy, the α‐C−H alkynylation of ethers, allylic compounds and 4‐thiazolidinone with aromatic terminal alkynes was also realized with a copper catalyst recently.…”

Copper‐Catalyzed Cross‐Dehydrogenative Coupling Reactions

“…Shaikh et al demonstrated an efficient protocol for C(sp 3 )À H alkynylation of 4-thiazolidinone with terminal alkynes using Cu as catalyst via cross-dehydrogenative coupling reaction. [29] The strategy involves the C(sp 3 )À C(sp) oxidative coupling of various 4-thiazolidines (17) with different terminal alkynes (18) using 10 mol% CuBr in DCE using TBHP as oxidant in air at 90°C (Scheme 5). The 4-thiazolidinone containing both electrondeficient and electron-rich groups showed good tolerance.…”

Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp2)–C(sp3) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones

“…In the recent years, cross-dehydrogenative coupling (CDC) reactions have received substantial interest. The major advancements made through studies in this area − have enabled CDC reactions to become highly attractive processes for formation of a variety of types of bonds. Particularly, interesting is the fact that these oxidative cross-coupling processes can be employed to form C–C bonds between two C–H components in an intermolecular − or intramolecular − manner.…”