Copper‐Binding Peptides Attenuate Microglia Inflammation through Suppression of NF‐kB Pathway

Caetano‐Silva, Maria Elisa; Rund, Laurie A.; Vailati-Riboni, Mario; Pacheco, Maria Teresa Bertoldo; Johnson, Rodney W.

doi:10.1002/mnfr.202100153

Cited by 21 publications

(8 citation statements)

References 49 publications

(64 reference statements)

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“…[ 40 ] Copper-binding peptides have also been shown to attenuate microglia inflammation by suppressing the NF-kB pathway field. [ 41 ] Consequently, the anti-inflammatory activity of copper is becoming a research hotspot.…”

Section: Discussionmentioning

confidence: 99%

Global status and research trends of cuprotosis research: A bibliometrics study via CiteSpace

Xie¹,

Liu

2023

Medicine

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Cuproptosis, a novel copper ion-dependent cell death type being regulated in cells, has raised concerns but lacks scientific analysis. Therefore, this study aimed to analyze the global status and emerging trends in cuprotosis research using bibliometric methods. Publications related to cuprotosis were systematically retrieved from the Web of Science Core Collection and then screened according to the inclusion criteria. Next, CiteSpace and Microsoft Excel 2021 were used to measure and visualize annual publications, categories, journals, countries, institutions, authors, co-cited references, and keywords to identify future global status and trends. A total of 2776 publications on cuprotosis were included, and the overall trend in the number of publications exhibited a rapid increase over the years. Biochemistry and Molecular Biology is the most common category, whereas the Journal of Inorganic Biochemistry is the most active. The United States is the country that produces the most articles, and University of Melbourne in Australia is the core institution involved in this field. Furthermore, Chan Pak of Stanford University is the most prolific author. Oxidative stress and antioxidant, the toxicity of copper in vitro, anticancer mechanism, and brain injury in neurological diseases are hot topics. The research frontiers are copper complexes, anticancer activity, DeoxyriboNucleic Acid binding, inflammation, and nanoparticles. This study provides the current status and trends in cuprotosis research. It may help researchers to identify hot topics and get ideas for future research directions in this field, focusing on copper complexes, anticancer activity, DeoxyriboNucleic Acid binding, inflammation, and nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Global status and research trends of cuprotosis research: A bibliometrics study via CiteSpace

Xie¹,

Liu

2023

Medicine

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“…It has been shown that Cu-binding peptide (Cu-bp) inhibits the translocation of NF-κB p65 to the nucleus to alleviate the inflammatory response of microglia. [ 59 ] Accumulation of copper in cells leads to disrupted mitochondrial autophagy and overexpression of the NLRP3/caspase-1/GSDMD protein axis in microglia. Copper also activates the secretion of NO, TNF-α and IL-6 by M1-type microglia.…”

Section: Mechanisms By Which Copper Overload Affects Cognitive Functionmentioning

confidence: 99%

Copper neurotoxicity: Induction of cognitive dysfunction: A review

Feng,

Zhao,

et al. 2023

Medicine

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Cognitive dysfunction occurs mainly in certain diseases and in the pathological process of aging. In addition to this, it is also widespread in patients undergoing anesthesia, surgery, and cancer chemotherapy. Neuroinflammation, oxidative stress, mitochondrial dysfunction, impaired synaptic plasticity, and lack of neurotrophic support are involved in copper-induced cognitive dysfunction. In addition, recent studies have found that copper mediates cuproptosis and adversely affects cognitive function. Cuproptosis is a copper-dependent, lipoylated mitochondrial protein-driven, non-apoptotic mode of regulated cell death, which provides us with new avenues for identifying and treating related diseases. However, the exact mechanism by which cuproptosis induces cognitive decline is still unclear, and this has attracted the interest of many researchers. In this paper, we analyzed the pathological mechanisms and therapeutic targets of copper-associated cognitive decline, mainly in the context of neurodegenerative diseases, psychiatric and psychological disorders, and diabetes mellitus.

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“…Numerous studies have found that proinflammatory microglia-mediated neurotoxicity in neurodegenerative diseases largely depends on the activation of the NF-κB pathway. Inhibition of NF-κB signaling selectively in microglia by chemicals can alleviate the production of pro-inflammation cytokines, chemokines, ROS, and nitric oxide, suppress LPS and other inflammatory trigger-induced microglial activation and attenuate microglia-mediated neuronal damage [ 20 , 21 , 22 ]. In a mouse model of ALS, NF-κB DNA-binding activity is predominately increased in microglia with disease progression.…”

Section: Nf-κb Pathway Is Essential For Microglial Activation and Sub...mentioning

confidence: 99%

Microglial Dysfunction in Neurodegenerative Diseases via RIPK1 and ROS

Zou

2022

Antioxidants

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Microglial dysfunction is a major contributor to the pathogenesis of multiple neurodegenerative diseases. The neurotoxicity of microglia associated with oxidative stress largely depends on NF-κB pathway activation, which promotes the production and release of microglial proinflammatory cytokines and chemokines. In this review, we discuss the current literature on the essential role of the NF-κB pathway on microglial activation that exacerbates neurodegeneration, with a particular focus on RIPK1 kinase activity-dependent microglial dysfunction. As upregulated RIPK1 kinase activity is associated with reactive oxygen species (ROS) accumulation in neurodegenerative diseases, we also discuss the current knowledge about the mechanistic links between RIPK1 activation and ROS generation. Given RIPK1 kinase activity and oxidative stress are closely regulated with each other in a vicious cycle, future studies are required to be conducted to fully understand how RIPK1 and ROS collude together to disturb microglial homeostasis that drives neurodegenerative pathogenesis.

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Copper‐Binding Peptides Attenuate Microglia Inflammation through Suppression of NF‐kB Pathway

Cited by 21 publications

References 49 publications

Global status and research trends of cuprotosis research: A bibliometrics study via CiteSpace

Global status and research trends of cuprotosis research: A bibliometrics study via CiteSpace

Copper neurotoxicity: Induction of cognitive dysfunction: A review

Microglial Dysfunction in Neurodegenerative Diseases via RIPK1 and ROS

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