Copper‐Based Hybrid Polyion Complexes for Fenton‐Like Reactions

Abstract

An innovative strategy allowing the development of a new generation of easy‐to‐prepare and easy‐to‐use nano‐sized catalysts with high tenability is presented. This strategy is based on the formation of hybrid polyion complexes (HPICs) from the complexation of copper with a block copolymer consisting of an ionizable complexing block and a neutral stabilizer block. These complexes have a well‐defined structure and size with a hydrodynamic diameter around 29 nm. They are stable in aqueous solution over a pH range from 4 to 8 and are not sensitive to NaCl salt addition or dilution effects. As a proof‐of‐concept the degradation of naphthol blue black in water through the use of the Fenton or photo‐Fenton reaction is studied. Their performances are comparable to a classical homogeneous reaction, whereas HPICs are easily recyclable by simple dialysis.

Copper nanocrystalline-doped folic acid-based super carbon dots for an enhanced antitumor effect in response to tumor microenvironment stimuli

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Hybrid Polymeric Nanostructures Stabilized by Ferric Cations with Photo-Fenton Performance: Implications for Recoverable Multicatalyst Design

“…Using HPICs obtained from the complexation of poly­(ethylene oxide)- block -poly­(acrylic acid), PEO- b -PAA, block copolymer, and Au III as a template, Seo et al reported the formation of gold nanoparticles, which can efficiently catalyze the reduction of a series of nitroarenes. Additionally, HPICs formed by the complexation of PEO- b -PAA and Cu 2+ ions exhibited good catalytic activity in the degradation of organic compounds based on a Fenton-like mechanism . Such pioneering studies have paved the way to nanostructures that are easy to synthesize and stable and have high potential as catalysts.…”

Tumor Microenvironment-Responsive BSA Nanocarriers For Combined Chemo/Chemodynamic Cancer Therapy

“…Chemodynamic therapy (CDT) based on the Fenton reaction, which catalyses hydrogen dioxide (H 2 O 2 ) into highly toxic hydroxyl radicals (•OH) by iron ions, has emerged as a novel therapeutic approach for cancer through oxidative damage of lipids, proteins and DNA [8]. Recently, copper-based Fenton-like reactions with higher reaction rates in a broader pH range showed more possibilities for highly e cient CDT [9][10][11][12][13]. However, copper is a trace element in the body incapable of inducing su cient therapeutic e cacy alone, which would induce toxicity to normal cells at high concentrations [14].…”