Copper and Zinc Levels in “Healthy” and “Sick” Elderly

Murphy, Peter J.; Wadiwala, I.; Sharland, D. E.; Rai, G. S.

doi:10.1111/j.1532-5415.1985.tb05437.x

Cited by 16 publications

(7 citation statements)

References 23 publications

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“…In contrast, however, Mutlu et al [6] did not find any difference in the concentration of copper between the serum of osteoporotic and healthy subjects. Similar results to those of Mutlu et al [6] were also obtained by Kotkowiak [7] and Murphy et al [8], while Massie et al [9] have shown that copper was negatively correlated with bone Ca concentrations. Consequently, Massie et al [9] have suggested that excess copper was the single most important factor associated with decreasing bone size and density.…”

Section: Introductionsupporting

confidence: 89%

Plasma Copper and Bone Mineral Density in Osteopenia: An Indicator of Bone Mineral Density in Osteopenic Females

Chaudhri

Kemmler

Harsch

et al. 2009

Biol Trace Elem Res

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Copper concentrations in blood plasma have been determined in 25 osteopenic females using inductively coupled plasma-mass spectrometry. A high degree of correlations has been demonstrated between the copper concentrations in plasma and the bone mineral density of the lumbar spine as measured using dual energy X-ray absorptiometry and quantitative computerized tomography. Results clearly indicate the involvement of copper in bone health and osteopenia. It is further suggested that plasma copper might be useful as a cheap and simple method indicative of bone mineral density in osteopenic postmenopausal females.

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Section: Introductionsupporting

confidence: 89%

Plasma Copper and Bone Mineral Density in Osteopenia: An Indicator of Bone Mineral Density in Osteopenic Females

Chaudhri

Kemmler

Harsch

et al. 2009

Biol Trace Elem Res

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“…Several studies reported that serum Zn and Cu levels were lower among patients with postmenopausal osteoporosis than controls [25-27]. In contrast, Reginster et al [16] significant difference in Zn and Cu plasma levels between two groups.…”

Section: Discussionmentioning

confidence: 99%

“…Three studies [25-27] in postmenopausal women have been shown lower nail Ca concentrations than in premenopausal women. Their BMD status showed a significant positive correlation with nail Ca content.…”

Section: Discussionmentioning

confidence: 99%

Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study

Razmandeh

Nasli‐Esfahani

Heydarpour

et al. 2014

J Diabetes Metab Disord

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BackgroundThe risk of inadequate nutrition such as trace elements and vitamin deficiencies is considerable in postmenopausal women. The aim of this study was to compare trace elements (Zinc, Copper and Magnesium) concentration in nail, urine and serum among osteoporotic postmenopausal women with control group in Iran.MethodsForty eight postmenopausal women aged 36–60 years, were recruited, consisting 30 osteoporotic patients and 18 healthy controls. Blood, nail and urine concentration of Zinc (Zn), copper (Cu) and magnesium (Mg) were determined using Inductively Coupled Plasma -Atomic Emission Spectrometry (ICP-AES) method. Their Bone Mineral Density was measured by Dual X-ray Absorption (DEXA) method.ResultsThe urine level of trace elements had significant difference between osteoporotic groups and controls (p < 0.001). Moreover Mg level significantly differed in serum between two groups (p < 0.04). There was no statistically significant difference in trace minerals in nail beyond groups.ConclusionOur findings indicate that Urine Zn level could be considerable an appropriate marker for bone absorption, usage of Zn supplements in postmenopausal women may result a beneficial reduction in osteoporotic risk.

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“…Zinc is essential for life and reproduction and is a component of the cell nucleus, mitochondria, cytoplasm, cell membranes, and cell walls [99]. Zinc is a constituent of about 300 enzymes, and Zn ions are located in the catalytic site as well as in the structural site of the enzyme complex [100,101]. …”

Section: Overview Of Brushite-forming Mg- Zn- and Sr-substituted mentioning

confidence: 99%

Brushite-Forming Mg-, Zn- and Sr-Substituted Bone Cements for Clinical Applications

Pina

Ferreira

2010

Materials

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Calcium phosphate cements have been in clinical use for the last 10 years. Their most salient features include good biocompatibility, excellent bioactivity, self-setting characteristics, low setting temperature, adequate stiffness, and easy shaping to accomodate any complicated geometry. They are commonly used in filling bone defects and trauma surgeries as mouldable paste-like bone substitute materials. Substitution of trace elements, such as Mg, Sr and Zn ions, into the structure of calcium phosphates is the subject of widespread investigation nowadays, because of their impending role in the biological process. Subtle differences in composition and structure of these materials may have a profound effect on their in vivo behaviour. Therefore, the main goal of this paper is to provide a simple, but comprehensive overview of the present achievements relating to brushite-forming cements doped with Mg, Zn and Sr, and to identify new developments and trends. In particular, the influence of ionic substitution on the chemical, physical and biological properties of these materials is discussed.

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Copper and Zinc Levels in “Healthy” and “Sick” Elderly

Cited by 16 publications

References 23 publications

Plasma Copper and Bone Mineral Density in Osteopenia: An Indicator of Bone Mineral Density in Osteopenic Females

Plasma Copper and Bone Mineral Density in Osteopenia: An Indicator of Bone Mineral Density in Osteopenic Females

Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study

Brushite-Forming Mg-, Zn- and Sr-Substituted Bone Cements for Clinical Applications

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