“…To the best of our knowledge, this study is the first to identify a relationship between the expression of Cu transporter genes and prognosis in HCC patients. These results support previous studies that described Cu levels as significantly higher in both patient serum [22][23][24][25] and resected tumors. [26][27][28] Considering the trend of poorer diseasefree survival for HCC patients with altered Cu transporter copy number (Fig.…”
Section: Discussionsupporting
confidence: 92%
“…Case studies of patients with Wilson Disease, which harbor germline mutations in the gene encoding the P-type ATPase ATP7B, 13,14 demonstrate that persistently elevated levels of intracellular Cu impair liver function such that HCC results as a complication. [15][16][17][18] Beyond the extensive research from both Wilson disease patients and animals that supports a connection between excessive Cu accumulation and hepatobiliary malignancies, [19][20][21] multiple clinical investigations observed elevated serum [22][23][24][25] and intratumoral [26][27][28] Cu levels in liver cancer patients. Notably, Cu lies at a unique intersection between chemistry and biology, as Cu-driven redox chemistry is required for a multitude of biological programs.…”
Hepatocellular carcinoma (HCC), the most common primary liver cancer, of which ~800,000 new cases will be diagnosed worldwide this year, portends a five-year survival rate of merely 17% in patients...
“…To the best of our knowledge, this study is the first to identify a relationship between the expression of Cu transporter genes and prognosis in HCC patients. These results support previous studies that described Cu levels as significantly higher in both patient serum [22][23][24][25] and resected tumors. [26][27][28] Considering the trend of poorer diseasefree survival for HCC patients with altered Cu transporter copy number (Fig.…”
Section: Discussionsupporting
confidence: 92%
“…Case studies of patients with Wilson Disease, which harbor germline mutations in the gene encoding the P-type ATPase ATP7B, 13,14 demonstrate that persistently elevated levels of intracellular Cu impair liver function such that HCC results as a complication. [15][16][17][18] Beyond the extensive research from both Wilson disease patients and animals that supports a connection between excessive Cu accumulation and hepatobiliary malignancies, [19][20][21] multiple clinical investigations observed elevated serum [22][23][24][25] and intratumoral [26][27][28] Cu levels in liver cancer patients. Notably, Cu lies at a unique intersection between chemistry and biology, as Cu-driven redox chemistry is required for a multitude of biological programs.…”
Hepatocellular carcinoma (HCC), the most common primary liver cancer, of which ~800,000 new cases will be diagnosed worldwide this year, portends a five-year survival rate of merely 17% in patients...
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