Copper and zinc concentrations in blood of patients with obstructive sleep apnea syndrome

Cofta, Szczepan; Wysocka, Ewa; Torliński, Lech; Goździk, Joanna

doi:10.5414/tep22001

Cited by 2 publications

(1 citation statement)

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“…There are few studies on serum copper in OSA patients documenting no changes [24] and increased Cu concentration in the severe stage of OSA but along with a consecutive hsCRP increase [25]. Other possible inflammatory-associated disorders, in which low total serum copper was suggested to predict high intracranial pressure (sensitivity 86% and specificity 73%) after traumatic brain injury [26] could be mentioned.…”

Section: Discussionmentioning

confidence: 99%

Oxidase activity of plasma ceruloplasmin in obstructive sleep apnea patients

Cymerys¹,

Cofta²,

Wysocka³

et al. 2013

cejoi

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Aim of the study: to analyze the oxidase activity of ceruloplasmin (Cp) Results: 1. all three osa groups did not differ in systolic (sBp) and diastolic (DBp) blood pressure and Cp-c. increased Cp-oa was observed in osa-1 and osa-2 groups, although the increased Cu was observed in osa-1, then decreased Cu was found in osa-2 and osa-3. 2. osa-1 patients were found to show positive relationships between Cp-oa and sBp, DBp and Cu, of which sBp correlated independently from others. in osa-2 group, Cp-oa was rather affected by aHi. osa-3 subjects presented positive correlations of sBp&BMi and sBp&aHi with an independent influence of aHi.Conclusions: we suggest some mobilization of plasma Cp activity in early stages of osa. the oxidase activity of plasma ceruloplasmin in normoglycemic osa patients may reflect some compensation for an increased activity of the sympathetic nervous system (elevated blood pressure) until there is severe osa pathology.

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Section: Discussionmentioning

confidence: 99%

Oxidase activity of plasma ceruloplasmin in obstructive sleep apnea patients

Cymerys¹,

Cofta²,

Wysocka³

et al. 2013

cejoi

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Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

Wallace

Gallagher

Peterson

et al. 2022

Preprint

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Background: Sleep disruption is a public health concern and environmental exposures that influence the biological processes underpinning sleep may contribute to impaired sleep health. However, the contributions of environmental chemical pollutants to sleep health have not been systematically investigated. Objectives: This systematic literature review sought to identify, evaluate, summarize, and synthesize the existing evidence between environmental chemical pollutant exposure and dimensions of sleep health in humans. We sought to evaluate potential mechanisms underlying exposure-outcome relationships and recommend areas for future research. Methods: Databases were searched for peer-reviewed published research on chemical environmental pollutants and sleep health and disorders with no date restriction up to the last search date of April 2021 (registered protocol PROSPERO # CRD42021256918), resulting in 9,918 records. Two reviewers independently screened identified records against inclusion and exclusion criteria, extracted study information, and performed risk of bias assessments. Results: We identified 204 studies of exposure to air pollution, exposures related to the Gulf War and other conflicts, endocrine disruptors, metals, pesticides, and solvents with dimensions of sleep health (architecture, duration, quality, timing) and sleep disorders (sleeping pill use, insomnia, sleep-disordered breathing) for inclusion in this review. Metals were the most frequently evaluated pollutants, while sleep maintenance/insomnia and quality were the most reported sleep outcomes. Synthesis of the evidence suggests mechanisms related to cholinergic signaling, neurotransmission, and inflammation as the most shared pathways. Discussion: Evidence indicates that exposure to particulate matter, secondhand smoke, dioxins and dioxin-like compounds, lead, mercury, pesticides, solvents, and exposures related to the Gulf War are associated with worse sleep health and disorders. Chemical pollutants are likely key environmental determinants of sleep health and disorders; thus, there is a need to improve measurement of pollutants and sleep, study rigor, and determine the populations most vulnerable to the effects of exposure.

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Copper and zinc concentrations in blood of patients with obstructive sleep apnea syndrome

Cited by 2 publications

References 0 publications

Oxidase activity of plasma ceruloplasmin in obstructive sleep apnea patients

Oxidase activity of plasma ceruloplasmin in obstructive sleep apnea patients

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

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