Copper-64-diacetyl-bis(
            <i>N</i>
            <sup>4</sup>
            -methylthiosemicarbazone): An agent for radiotherapy

Lewis, Jason S.; Laforest, Richard; Buettner, Thomas; Song, Sheng; Fujibayashi, Yasuhisa; Connett, Judith M.; Welch, Michael J.

doi:10.1073/pnas.98.3.1206

Cited by 198 publications

(173 citation statements)

References 28 publications

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“…Copper (Cu), one of the first‐row transition metals, is essential in the human body as part of enzymes, and also could be applied in medical research and clinical practice for radiotherapy of cancer cell 215. Hence Cu is relatively environmentally friendly, which is also used as a plain conductor in our daily life.…”

Section: Lead‐free Halide Hybrid Perovskite and Related Absorbersmentioning

confidence: 99%

Lead‐Free Hybrid Perovskite Absorbers for Viable Application: Can We Eat the Cake and Have It too?

2017

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Many years since the booming of research on perovskite solar cells (PSCs), the hybrid perovskite materials developed for photovoltaic application form three main categories since 2009: (i) high‐performance unstable lead‐containing perovskites, (ii) low‐performance lead‐free perovskites, and (iii) moderate performance and stable lead‐containing perovskites. The search for alternative materials to replace lead leads to the second group of perovskite materials. To date, a number of these compounds have been synthesized and applied in photovoltaic devices. Here, lead‐free hybrid light absorbers used in PV devices are focused and their recent developments in related solar cell applications are reviewed comprehensively. In the first part, group 14 metals (Sn and Ge)‐based perovskites are introduced with more emphasis on the optimization of Sn‐based PSCs. Then concerns on halide hybrids of group 15 metals (Bi and Sb) are raised, which are mainly perovskite derivatives. At the same time, transition metal Cu‐based perovskites are also referred. In the end, an outlook is given on the design strategy of lead‐free halide hybrid absorbers for photovoltaic applications. It is believed that this timely review can represent our unique view of the field and shed some light on the direction of development of such promising materials.

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Section: Lead‐free Halide Hybrid Perovskite and Related Absorbersmentioning

confidence: 99%

Lead‐Free Hybrid Perovskite Absorbers for Viable Application: Can We Eat the Cake and Have It too?

2017

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Section: Discussionmentioning

confidence: 99%

“…However, the beta emission and long half-life result in a relatively high local radiation dose, making 64 Cu radiotracers less desirable for clinical diagnostic studies. However, the high spatial resolution makes 64 Cu-ATSM and 64 Cu-PTSM well suited for imaging in animal experiments, and the beta emission from 64 Cu-ATSM could potentially be used to enhance local radiation therapy to hypoxic regions of tumor [11,12].Using 62 Cu radiotracers for PET offers several advantages: The short half-life (9.7 minutes) allows multiple imaging studies to be performed and results in significantly less radiation dose to the patient compared with the other copper radionuclides. In this pilot study, we have shown the feasibility of obtaining 62 Cu-ATSM and 62 Cu-PTSM PET scans during a single imaging session; these scans independently provide information about hypoxia and perfusion, respectively.…”

mentioning

confidence: 99%

PET of Hypoxia and Perfusion with ⁶²Cu-ATSM and ⁶²Cu-PTSM Using a ⁶²Zn/⁶²Cu Generator

Wong

Lacy

Petry

et al. 2008

American Journal of Roentgenology

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OBJECTIVE-Copper-diacetyl-bis(N 4 -methylthiosemicarbazone) (Cu-ATSM) and copperpyruvaldehyde-bis(N 4 -methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g., 62 Cu) has advantages for clinical PET, including a lower radiation dose than long-lived radionuclides and serial imaging capability. A 62 Zn/ 62 Cu microgenerator and rapid synthesis kits now provide a practical means of producing 62 Cu-PTSM and 62 Cu-ATSM on-site. Tumors can be characterized with 62 Cu-PTSM, 62 Cu-ATSM, and 18 F-FDG PET scans during one session. We present the initial clinical data in two patients with lung neoplasms.CONCLUSION-Hypoxia and perfusion are important parameters in tumor physiology and can have major implications in diagnosis, prognosis, treatment planning, and response to therapy. We have shown the feasibility of performing 62 Cu-ATSM and 62 Cu-PTSM PET together with FDG PET/ CT during a single imaging session to provide information on both perfusion and hypoxia and tumor anatomy and metabolism. Keywords granuloma; lung cancer; perfusion imaging; PET/CT; radionuclides; tumor hypoxia Tumor hypoxia is a critical factor in both the development and treatment of malignant disease. Hypoxia and altered angiogenesis are critical factors in carcinogenesis, and hypoxic tumors are more resistant to both radiation and chemotherapy than tumors that are not hypoxic. Tumor hypoxia has been shown to correlate with poorer prognosis in head and neck cancer and cervical cancer and may have similar negative prognostic implications in other malignancies. For these reasons, there is a compelling interest to develop techniques for imaging tumor hypoxia; these imaging techniques would increase the current understanding of tumor physiology and would have immediate applicability in guiding cytotoxic chemotherapy, radiation therapy, and the use of antiangiogenic agents. PET can provide quantitative information about positron-emitting Address correspondence to T. Z. Wong (wong0015@mc.duke.edu). J. L. Lacy is president of Proportional Technologies, Inc., Houston, TX. (Fig. 1) was scheduled for delivery on the day of PET scanning. NIH Public Access PatientsFor this preliminary clinical study, two patients with lung nodules (> 1 cm) suspicious for malignancy were enrolled. PET was performed to evaluate these lesions before surgical resection. The purpose of this research study was to determine the feasibility of imaging lung tumors using the 62 Zn/ 62 Cu generator and to compare the imaging findings with surgical pathology. The clinical protocol was approved by our institutional review board, and written informed consent was obtained from both patients. Regional PET images of the thorax were obtained using 62 Cu-ATSM and 62 Cu-PTSM. A routine clinical PET scan using FDG was also obtained in each patient for preoperative staging. PETImaging was performed using a PET/CT scanner (Discovery ST, GE Healthcare) with a 16-MDCT unit. CT-based attenuati...

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“…First, Cu is relatively easy to incorporate in molecules and has multiple radioactive isotopes suitable for PET imaging. Second, with half lives ranging from 24 min to 13h for 60 Cu and 64 Cu, respectively, Cu has several potential applications. The short-lived radionuclides can be used for sequential measurements, whereas radionuclides with longer half lives do Table 2 for full names.…”

Section: F]fetnim and [mentioning

confidence: 99%

“…Refer to Cu can also be applied as radiation therapy agent, since it also emits a β -particle (40% yield) [64,65] . In oncology, [Cu]ATSM has been evaluated both preclinically and clinically.…”

Section: F]fmisomentioning

confidence: 99%

Positron emission tomography to assess hypoxia and perfusion in lung cancer

Verwer

Boellaard

Veldt

2014

WJCO

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Core tip:This review provides an overview of the current applications of positron emission tomography for hypoxia and perfusion imaging in lung cancer. Available PET tracers are discussed and the benefits of combined hypoxia and perfusion PET imaging are clarified. Hypoxia imaging could aid in selecting patients for hypoxia-specific treatment strategies. To achieve this, consensus about the optimal imaging protocol and quantification method is essential. Large clinical trials are needed to confirm the value of hypoxia imaging for improving patient care.Verwer EE, Boellaard R, van der Veldt AAM. Positron emission tomography to assess hypoxia and perfusion in lung cancer.

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Copper-64-diacetyl-bis( N ⁴ -methylthiosemicarbazone): An agent for radiotherapy

Cited by 198 publications

References 28 publications

Lead‐Free Hybrid Perovskite Absorbers for Viable Application: Can We Eat the Cake and Have It too?

Lead‐Free Hybrid Perovskite Absorbers for Viable Application: Can We Eat the Cake and Have It too?

PET of Hypoxia and Perfusion with ⁶²Cu-ATSM and ⁶²Cu-PTSM Using a ⁶²Zn/⁶²Cu Generator

Positron emission tomography to assess hypoxia and perfusion in lung cancer

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Copper-64-diacetyl-bis( N 4 -methylthiosemicarbazone): An agent for radiotherapy

Cited by 198 publications

References 28 publications

Lead‐Free Hybrid Perovskite Absorbers for Viable Application: Can We Eat the Cake and Have It too?

Lead‐Free Hybrid Perovskite Absorbers for Viable Application: Can We Eat the Cake and Have It too?

PET of Hypoxia and Perfusion with 62Cu-ATSM and 62Cu-PTSM Using a 62Zn/62Cu Generator

Positron emission tomography to assess hypoxia and perfusion in lung cancer

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Product

Resources

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Copper-64-diacetyl-bis( N ⁴ -methylthiosemicarbazone): An agent for radiotherapy

PET of Hypoxia and Perfusion with ⁶²Cu-ATSM and ⁶²Cu-PTSM Using a ⁶²Zn/⁶²Cu Generator