Copolymers of D,L‐lactic acid and glycine

Enzyme-catalyzed ring-opening polymerization of 3(S)-isopropylmorpholine-2,5-dione

“…The copolymerization of morpholine-2,5-diones with D,L-lactid (DLLA), glycolid (GA) or e-caprolactone (CL) produces poly-(esteramides) with a variety of properties [6][7][8] . The degradation of random copolymers of morpholine-2,5-diones with DLLA or CL was studied by Helder et al 7) and In't Veld et al 8) Their results indicate that the copolymers degrade faster than the homopolymers, poly(DLLA) and poly(CL).…”

Concept and Synthesis of Poly(ester amide)s with One Isolated, Two or Three Consecutive Amide Bonds Randomly Distributed Along the Polyester Backbone

“…Condensation of α,ω-amino alcohols with cyclic anhydrides results in preformed linear AB monomers (α-carboxyl-ω-hydroxy amides) which can be polymerized to yield strictly alternating PEAs [20][21][22][23][24]. Ring-opening polymerization of morpholine-2,5-dione derivatives is yet another synthetic route to obtain alternating PEAs [25][26][27][28][29][30][31][32][33][34][35][36]. The polymerization proceeds by cleavage of the ester bond to give an alternating sequence of α-hydroxy acid and α-amino-acid residues.…”

“…Synthesis of alternating polydepsipeptides consisting of different combinations of α-amino acids (such as glycine, alanine or valine) and α-hydroxy acids (such as glycolic or lactic acid) gives rise to PEAs with varying hydrophilicity, crystallinity and mechanical stability [28,29,31,[85][86][87]. However, in order to obtain semi-crystalline alternating PEAs, an enantiospecific route is required.…”

“…However, in order to obtain semi-crystalline alternating PEAs, an enantiospecific route is required. Feijen and co-workers [25,27,28,88,89] have carried out the ring-opening homo-polymerization of 3-alkyl substituted morpholine-2,5-dione derivatives and the co-polymerization of 3-alkyl substituted morpholine-2,5-dione derivatives with D,L-lactic acid or ε-caprolactone using stannous octoate as an initiator. This resulted in PEAs which had no chemically modifiable pendant groups.…”

Synthesis and characteristics of polydepsipeptide with pendant thiol groups

“…We can assign medical polymers. poly(a-hydroxy acid) as an example of materials On the other hand, the polydepsipeptides, [7][8][9][10][11][12][13][14][15][16][17][18][19] degraded for a given period. Poly(a-hydroxy copolymers of a-amino acids and a-hydroxy acids, acid)s, such as poly(lactic acid) [poly(LA)] and are also known to be biodegradable polymers.…”