Copolymer-1 as a potential therapy for mild cognitive impairment

Incontri‐Abraham, Diego; Salazar, Felipe Esparza; Ibarra, Antonio

doi:10.1016/j.bandc.2022.105892

Cited by 2 publications

(2 citation statements)

References 154 publications

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“…GA has been assumed to be an immunomodulatory agent with neuroprotective properties in various neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis [ 113 , 114 , 115 , 116 ]. Furthermore, it has been established that GA also wields a suppressive impact on the M1 phenotype of microglia while concurrently encouraging the M2 phenotype.…”

Section: Immunomodulatory Peptides After Spinal Cord Injurymentioning

confidence: 99%

“…This combined approach demonstrated that after SCI, the combination therapy outperformed the standalone immunization, leading to improved motor recovery, a higher count of myelinated axons, and enhanced survival of rubrospinal neurons. GSHE’s action in reducing ROS levels and lipid peroxidation does not interfere with the therapeutic effect of A91, thereby establishing the superiority of the A91-GSHE combination when administered shortly after SCI or within the initial 72 h post-injury period [ 115 , 116 ].…”

Section: Immunomodulatory Peptides After Spinal Cord Injurymentioning

confidence: 99%

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Use of Cells, Supplements, and Peptides as Therapeutic Strategies for Modulating Inflammation after Spinal Cord Injury: An Update

Garcia,

Buzoianu-Anguiano,

Silva-Garcia

et al. 2023

IJMS

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Spinal cord injury is a traumatic lesion that causes a catastrophic condition in patients, resulting in neuronal deficit and loss of motor and sensory function. That loss is caused by secondary injury events following mechanical damage, which results in cell death. One of the most important events is inflammation, which activates molecules like proinflammatory cytokines (IL-1β, IFN-γ, and TNF-α) that provoke a toxic environment, inhibiting axonal growth and exacerbating CNS damage. As there is no effective treatment, one of the developed therapies is neuroprotection of the tissue to preserve healthy tissue. Among the strategies that have been developed are the use of cell therapy, the use of peptides, and molecules or supplements that have been shown to favor an anti-inflammatory environment that helps to preserve tissue and cells at the site of injury, thus favoring axonal growth and improved locomotor function. In this review, we will explain some of these strategies used in different animal models of spinal cord injury, their activity as modulators of the immune system, and the benefits they have shown.

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Section: Immunomodulatory Peptides After Spinal Cord Injurymentioning

confidence: 99%

Section: Immunomodulatory Peptides After Spinal Cord Injurymentioning

confidence: 99%

Use of Cells, Supplements, and Peptides as Therapeutic Strategies for Modulating Inflammation after Spinal Cord Injury: An Update

Garcia,

Buzoianu-Anguiano,

Silva-Garcia

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Use of Cells, Supplements and Peptides as Therapeutic Strategies for Modulating Inflammation after Spinal Cord Injury: An Update

García,

Buzoianu-Anguiano,

Silva Garcia

et al. 2023

Preprint

View full text Add to dashboard Cite

Spinal cord injury is a traumatic injury that causes a catastrophic state in patients due to neuronal deficits, loss of motor and sensory function, and this is due to secondary deleterious events subsequent to mechanical damage that expands the death of neural cells beyond the initial trauma. One of the most important events is inflammation, which activates molecules like pro-inflammatory cytokines (IL-1beta, IFN-gamma, TNF-alpha) that provoke a toxic environment, inhibiting axonal growth and exacerbating CNS damage. As there is no effective treatment, one of the strategies developed is neuroprotection to preserve healthy neural tissue and reduce neuroinflammation. Some of the neuroprotective treatments that have been practiced are the use of cell therapy, the administration of peptides and molecules or supplements that have been shown to favor an anti-inflammatory environment, and help to preserve the cells and tissues surrounding the injured area, favoring axonal growth and improving locomotor function. In this review we will explain some of these strategies used in different animal models of spinal cord injury, their activity as modulators of the immune system and the benefits they have shown.

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Copolymer-1 as a potential therapy for mild cognitive impairment

Cited by 2 publications

References 154 publications

Use of Cells, Supplements, and Peptides as Therapeutic Strategies for Modulating Inflammation after Spinal Cord Injury: An Update

Use of Cells, Supplements, and Peptides as Therapeutic Strategies for Modulating Inflammation after Spinal Cord Injury: An Update

Use of Cells, Supplements and Peptides as Therapeutic Strategies for Modulating Inflammation after Spinal Cord Injury: An Update

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