Coping strategies have a strong impact on quality of life, depression, and embitterment in patients with Cushing’s disease

Siegel, Sonja; Milian, Monika; Kleist, Bernadette; Psaras, Tsambika; Tsiogka, Maria; Führer, Dagmar; Kołtowska-Häggström, Maria; Honegger, Jürgen; Müller, Oliver; Sure, Ulrich; Menzel, Christa; Buchfelder, Michael; Kreitschmann-Andermahr, Ilonka

doi:10.1007/s11102-016-0750-1

Cited by 19 publications

(48 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More specifically, using SF-36, improvements were found for bodily pain, vitality, social functioning, role limitations due to emotional health, general health, mental health and mental summary scores; while no improvement was found for physical functioning, role limitations for physical health and physical summary (35). SF-36 scores in patients surgically treated for CD have showed more impairment in women, specifically for physical functioning, physical role functioning and emotional role functioning (40).…”

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 96%

“…Some degree of embitterment was found in more than a half of the patients compared to reference values. Specifically 36.8% of the patients had a medium degree of embitterment, 18.7% had an above-average degree of embitterment and 3.5% had an extreme degree of embitterment (40) Cognitive function, including memory and executive functions, remains impaired after cure of CD. This has been found 1 year after biochemical cure (85,86), 3 years after surgery for CS (9) and also in patients with long-term remission, with lower scores when compared to healthy controls and non-functioning adenomas (6,82,87,88).…”

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 98%

“…In a focus group study including 6 patients with CD some maladaptive coping strategies (as overdoing or problems with acceptance) were identified as possible contributors of low QoL (84). In fact, a further study found that maladaptative coping strategies (mainly depressive coping, trivialization, and wishful thinking) were correlated to different measures, indicating a relationship with poorer QoL (measures with both Tuebingem CD-25 and SF-36) and higher depression, anxiety and embitterment (40). Furthermore, QoL scores were also related to embitterment (measured with the Bern embitterment questionnaire-BEI).…”

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 98%

“…Another study reported impairment in the 6 dimensions of Tuebingem 25-CD questionnaire in patients treated for CD (85% in remission after surgery) (75). In addition, women were more affected than men for the dimensions of eating behavior and cognition of the Tuebingem 25-CD questionnaire (40).…”

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 98%

“…It is now clear that CS and CD have a deleterious effect on the QoL of the affected patients, although the extent may vary from one patient to another. Different determinants have been described that impact on quality of life (12,22,29,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). A summary can be found in Figure 1.…”

Section: What Are the Effects Of Cushing's Syndrome On Health-relatedmentioning

confidence: 99%

See 4 more Smart Citations

Quality of Life in Patients With Cushing's Disease

et al. 2019

View full text Add to dashboard Cite

Cushing's disease (and by extension, Cushing's syndrome) is a rare disease due to a chronic cortisol excess, which usually has an important impact on quality of life (QoL). It can lead to numerous comorbidities that can interfere with daily life, as fatigability, myopathy, bone loss and fragility, increased cardiovascular risk, depression, and cognitive alterations. Of note, psychological alterations (including depression and anxiety) occur often, and are an important determinant of impaired quality QoL. QoL scores using different questionnaires are poorer in comparison to healthy controls, other pituitary adenomas and some chronic diseases. Even if some improvements can be observed after successful treatment, recovery does not seem to be complete, and comorbidities persist. This persistent QoL impairment has been found using both generic and disease-specific QoL questionnaires, and is also reported by the patients themselves, when asked directly. Multidisciplinary teams are essential to improve patients' well-being. Clinicians should take into account the whole scope of clinical problems and address the different comorbidites associated with the disease. Screening in the psychological sphere, with further intervention if necessary, can be helpful in the management of these patients. Interventions and programs have shown promising results, although there is a need for further development of new strategies for the benefit of these patients.

show abstract

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 96%

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 98%

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 98%

Section: Effects Of Remission In Quality Of Lifementioning

confidence: 98%

Section: What Are the Effects Of Cushing's Syndrome On Health-relatedmentioning

confidence: 99%

See 3 more Smart Citations

Quality of Life in Patients With Cushing's Disease

et al. 2019

View full text Add to dashboard Cite

show abstract

Holistic burden of illness in patients with endogenous Cushing's syndrome: A systematic literature review

Page‐Wilson,

Oak,

Silber

et al. 2023

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

ObjectiveThe objective of this systematic literature review (SLR) was to summarize the latest studies evaluating the burden of illness in endogenous Cushing's syndrome (CS), including the impact of CS on overall and domain‐specific health‐related quality of life (HRQoL) and the economic burden of CS to provide a holistic understanding of disease and treatment burden.MethodsAn SLR was conducted in PubMed, MEDLINE and Embase using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) checklist to identify peer‐reviewed manuscripts and conference abstracts published in English from 2015 to December 4, 2020.ResultsForty‐five publications were eligible for inclusion; data were extracted from 37 primary studies while 8 SLRs were included for reference only. Thirty‐one studies reported HRQoL using validated patient reported outcome (PRO) measures in pre‐ or post‐surgery, radiotherapy and pharmacotherapy patients. Overall, this SLR found that patients with CS have worse outcomes relative to healthy populations across specific dimensions, such as depression, despite an improvement in HRQoL post‐treatment. These findings reveal that CS symptoms are not fully resolved by the existing care paradigm. Few studies report on the economic burden of CS and currently available data indicate a high direct healthcare system cost burden.ConclusionsPatients with CS experience a significant, complex and multifactorial HRQoL burden. Symptom‐specific burden studies are sparse in the literature and the understanding of long‐term CS symptomatic burden and economic burden is limited. This review intends to provide an updated reference for clinicians, payers and other stakeholders on the burden of CS as reported in published literature and to encourage further research in this area.

show abstract