Coping strategies and anxiety in association with methotrexate-induced nausea in juvenile idiopathic arthritis

Kyvsgaard, Nini; Thastum, Mikael; Mikkelsen, Torben Stamm; Christensen, Anne Estmann; Herlin, Troels

doi:10.1007/s00296-020-04520-9

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…The authors proposed that psychological factors may therefore be part of the mechanism behind the inter-individual variation in the level of nausea to methotrexate treatment. 42 In another study of parents of 230 CYP with JIA on methotrexate for at least six months, fear of injections and/or blood tests rated as often or almost always was reported in over a third of CYP with over half reported as experiencing them at least sometimes. Anxiety related to blood tests was an independent predictor for poorer scores in the psychosocial scales of quality of life.…”

Section: Specific Anxiety Inducing Proceduresmentioning

confidence: 99%

<p>Young Minds: Mental Health and Transitional Care in Adolescent and Young Adult Rheumatology</p>

Palman¹,

McDonagh²

2020

OARRR

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Section: Specific Anxiety Inducing Proceduresmentioning

confidence: 99%

<p>Young Minds: Mental Health and Transitional Care in Adolescent and Young Adult Rheumatology</p>

Palman¹,

McDonagh²

2020

OARRR

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“…This recommendation to use IAS for children with a few joints involved is based on a desire to minimize toxicity and cost associated with systemic treatment while minimizing joint damage and long term morbidity. Methotrexate intolerance, which primarily manifests as nausea and vomiting, occurs in up to 50% of children and is associated with decreased quality of life [ 2 – 6 ]. The prevalence of methotrexate intolerance appears to increase with prolonged duration of treatment and occurs regardless of the route of delivery (oral or subcutaneous).…”

Section: Introductionmentioning

confidence: 99%

Intraarticular steroids as DMARD-sparing agents for juvenile idiopathic arthritis flares: Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry

Daymont

Groh

Hays³

et al. 2022

Pediatr Rheumatol

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Background Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience a flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment with disease modifying anti-rheumatic drugs (DMARDs). IAS offer an opportunity to recapture disease control and avoid exposure to side effects from systemic immunosuppression. We examined a cohort of patients treated with IAS after drug free remission and report the probability of restarting systemic treatment within 12 months. Methods We analyzed a cohort of patients from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry who received IAS for a flare after a period of drug free remission. Historical factors and clinical characteristics and of the patients including data obtained at the time of treatment were analyzed. Results We identified 46 patients who met the inclusion criteria. Of those with follow up data available 49% had restarted systemic treatment 6 months after IAS injection and 70% had restarted systemic treatment at 12 months. The proportion of patients with prior use of a biologic DMARD was the only factor that differed between patients who restarted systemic treatment those who did not, both at 6 months (79% vs 35%, p < 0.01) and 12 months (81% vs 33%, p < 0.05). Conclusion While IAS are an option for all patients who flare after drug free remission, it may not prevent the need to restart systemic treatment. Prior use of a biologic DMARD may predict lack of success for IAS. Those who previously received methotrexate only, on the other hand, are excellent candidates for IAS.

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“…A study by Kyvsgaard et al [ 88 ] reported that among children experiencing methotrexate-induced nausea, as determined by either the Methotrexate Intolerance Severity Score (MISS) or a nausea diary, there was a higher frequency of utilising the coping strategy of catastrophizing compared to other children. These psychological factors could contribute to the mechanism underlying individual differences in the severity of MTX-induced nausea in children with JIA [ 88 ].…”

Section: Search Methodologymentioning

confidence: 99%

Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications

Wilk,

Zimba,

Haugeberg

et al. 2024

Rheumatol Int

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Pain is a crucial factor in rheumatic disorders, and reducing it is a primary goal of successful treatment. Adaptive pain-coping strategies can enhance this improvement, but maladaptive approaches such as pain catastrophizing may worsen overall patient well-being. This narrative review aims to provide a concise overview of the existing knowledge on pain catastrophizing in the most prevalent specific rheumatic disorders. The objective of this study was to improve understanding of this phenomenon and its implications, as well as to pinpoint potential directions for future research. We conducted searches in the MEDLINE/PubMed, SCOPUS, and DOAJ bibliography databases to identify articles related to pain catastrophizing in rheumatoid arthritis, psoriatic arthritis, axial spondylarthritis, systemic sclerosis, systemic lupus erythematosus, Sjögren’s syndrome, juvenile idiopathic arthritis, and osteoarthritis (non-surgical treatment). Data extraction was performed on November 1, 2023. The investigators screened the identified articles to determine their relevance and whether they met the inclusion criteria. Following a bibliography search, which was further expanded by screening of citations and references, we included 156 records in the current review. The full-text analysis centred on pain catastrophizing, encompassing its prevalence, pathogenesis, and impact. The review established the role of catastrophizing in amplifying pain and diminishing various aspects of general well-being. Also, potential treatment approaches were discussed and summarised across the examined disorders. Pain catastrophizing is as a significant factor in rheumatic disorders. Its impact warrants further exploration through prospective controlled trials to enhance global patient outcomes.

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Coping strategies and anxiety in association with methotrexate-induced nausea in juvenile idiopathic arthritis

Cited by 9 publications

References 28 publications

<p>Young Minds: Mental Health and Transitional Care in Adolescent and Young Adult Rheumatology</p>

<p>Young Minds: Mental Health and Transitional Care in Adolescent and Young Adult Rheumatology</p>

Intraarticular steroids as DMARD-sparing agents for juvenile idiopathic arthritis flares: Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry

Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications

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