Coping Skills Are Associated With Gastrointestinal Symptom Severity and Somatization in Patients With Irritable Bowel Syndrome

Wilpart, Katarina; Törnblom, Hans; Svedlund, Jan; Tack, Jan; Simrén, Magnus; Oudenhove, Lukas Van

doi:10.1016/j.cgh.2017.02.032

Cited by 32 publications

(31 citation statements)

References 44 publications

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“…28 Taken together, these findings indicate that fearful anticipation of painful visceral stimuli, as well as the context in which it occurs, may modulate subsequent brain responses to delivery of these stimuli in sensory as well as affective regions, and that these processes may go awry in IBS patients. This fits with the clinical observation that GI-specific fear and anxiety levels, 31 as well as levels of coping resources, 78 are associated with IBS symptom severity and course.…”

Section: Influence Of Life Events Stress and Other Affective Statessupporting

confidence: 88%

The gut–brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation

Weltens

Iven

Oudenhove

et al. 2018

Annals of the New York Academy of Sciences

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Over the past few years, scientific interest in the gut-brain axis (i.e., the bidirectional communication system between the gastrointestinal tract and the brain) has exploded, mostly due to the identification of the gut microbiota as a novel key player in this communication. However, important progress has also been made in other aspects of gut-brain axis research, which has been relatively underemphasized in the review literature. Therefore, in this review, we provide a comprehensive, although not exhaustive, overview of recent research on the functional neuroanatomy of the gutbrain axis and its relevance toward the multidisciplinary field of health neuroscience, excluding studies on the role of the gut microbiota. More specifically, we first focus on irritable bowel syndrome, after which we outline recent findings on the role of the gut-brain axis in appetite and feeding regulation, primarily focusing on the impact of subliminal nutrient-related gut-brain signals. We conclude by providing future perspectives to facilitate translation of the findings from gut-brain axis neuroscientific research to clinical applications in these domains.

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Section: Influence Of Life Events Stress and Other Affective Statessupporting

confidence: 88%

The gut–brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation

Weltens

Iven

Oudenhove

et al. 2018

Annals of the New York Academy of Sciences

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“…The information of studies related to depressive symptoms has been summarised in Table S3. Analysis of 47 articles indicated that the pooled prevalence of depressive symptoms was 28.8% (95% CI: 23.6‐34; I 2 = 99.1%) in 22 842 IBS patients (Figure ). Visual inspection of the funnel plot indicates some asymmetry (Figure S5).…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta‐analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome

Zamani

Alizadeh-Tabari

Zamani

2019

Aliment Pharmacol Ther

270

195

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Background: Irritable bowel syndrome (IBS) is a common and potential disabling functional gastrointestinal disorder. Studies have revealed a possible association between IBS and psychological problems, such as anxiety and depression. Existing systematic reviews have addressed only the levels of anxiety or depression in patients with IBS. Aim:To investigate systematically the prevalence of anxiety or depression in IBS patients Methods: A literature search was conducted using the related keywords from the bibliographic databases of Embase, PubMed, Scopus, Web of Science and POPLINE published until 1 January 2019 with no language restriction. Studies reporting the prevalence of anxiety/depressive symptoms/disorders in adult (≥15 years) IBS patients were evaluated. The pooled prevalence, odds ratio (OR) and 95% CI were calculated using stata software.Results: A total of 14 926 articles were initially screened, and finally 73 papers were included. The prevalence rates of anxiety symptoms and disorders in IBS patients were 39.1% (95% CI: 32.4-45.8) and 23% (95% CI: 17.2-28.8) respectively. The ORs for anxiety symptoms and disorders in IBS patients compared with healthy subjects were 3.11 (95% CI: 2.43-3.98) and 2.52 (95% CI: 1.99-3.20) respectively. The prevalence estimates of depressive symptoms and disorders in IBS patients were 28.8% (95% CI: 23.6-34) and 23.3% (95% CI: 17.2-29.4) respectively. The ORs for depressive symptoms and disorders in IBS patients compared to healthy subjects were 3.04 (95% CI: 2.37-3.91) and 2.72 (95% CI: 2.45-3.02) respectively. Conclusion: Patients with IBS have a three-fold increased odds of either anxiety or depression, compared to healthy subjects. | 133 ZAMANI et Al. S U PP O RTI N G I N FO R M ATI O N Additional supporting information will be found online in the Supporting Information section at the end of the article. How to cite this article: Zamani M, Alizadeh-Tabari S, Zamani V. Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2019;50:132-143. https ://

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“…Many patients with FAPDs have reduced quality of life and functioning . The reason for this is unclear but may be related to a high number of comorbidities (including gastrointestinal, extra‐intestinal, and psychological) in addition to reduced coping skills . Despite evolving knowledge of aberrant brain‐gut signaling in patients with functional GI disorders, psychological disease is still often considered the only root of the problem.…”

Section: Discussionmentioning

confidence: 99%

Nausea exacerbates symptom burden, quality of life, and functioning in adolescents with functional abdominal pain disorders

Kovacic

Kapavarapu

Sood

et al. 2019

Neurogastroenterology Motil

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Abbreviations: ANS, autonomic nervous system; FAPDs, functional abdominal pain disorders; FDI, functional disability inventory; FGIDs, functional gastrointestinal disorders; GI, gastrointestinal; IBS, irritable bowel syndrome; IQR, interquartile range; NPQ, nausea profile questionnaire; PROMIS, patient-reported outcome measurement information system; QoL, quality of life; QPGS-III, Questionnaire on Pediatric Gastrointestinal Symptoms Rome III version; STAI-C, state-trait anxiety inventory for children. AbstractBackground: Nausea frequently co-exists with functional abdominal pain disorders (FAPDs) and may be linked to a higher disease burden. This study aimed to prospectively compare multisystem symptoms, quality of life, and functioning in FAPDs with and without nausea. Methods: Adolescents ages 11-18 years fulfilling Rome III criteria for a FAPD were grouped by the presence or absence of chronic nausea. Subjects completed validated instruments assessing nausea (Nausea Profile Questionnaire = NPQ), quality of life (Patient-Reported Outcome Measurement Information System), functioning (Functional Disability Inventory), and anxiety (State-Trait Anxiety Inventory for Children). Group comparisons were performed for instruments, multisystem symptoms, school absences, and clinical diagnoses. Key Results: A total of 112 subjects were included; 71% reported chronic nausea.Patients with Nausea compared to No Nausea had higher NPQ scores (P ≤ 0.001), worse quality of life (P = 0.004), and greater disability (P = 0.02). State and trait anxiety scores were similar (P = 0.57, P = 0.25). A higher NPQ score correlated with poorer quality of life, more disability, and higher anxiety. Specific comorbidities were more common in Nausea vs No Nausea group: dizziness (81% vs 41%; P ≤ 0.001), concentrating difficulties (68% vs 27%; P ≤ 0.001), chronic fatigue (58% vs 20%; P = 0.01), and sleep disturbances (73% vs 48%; P = 0.02). The Nausea group reported more school absences (P = 0.001) and more commonly met criteria for functional dyspepsia (P = 0.034). Conclusion and Inferences:Nausea co-existing with FAPDs is associated with a higher extra-intestinal symptom burden, worse quality of life, and impaired functioning in children. Assessing and targeting nausea therapeutically is essential to improve outcomes in FAPDs.

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Coping Skills Are Associated With Gastrointestinal Symptom Severity and Somatization in Patients With Irritable Bowel Syndrome

Cited by 32 publications

References 44 publications

The gut–brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation

The gut–brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation

Systematic review with meta‐analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome

Nausea exacerbates symptom burden, quality of life, and functioning in adolescents with functional abdominal pain disorders

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