Objective
Apply the National Institutes of Health (NIH) Stage Model to design and test an intervention to prevent depression in breast cancer patients at risk for depression.
Methods
We identified mindful emotion awareness, along with approach and avoidance strategies for cancerârelated coping and emotion regulation, as targets for a preventive intervention adapted from the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders. Patients' preferences for individual, inâperson, and timeâefficient sessions informed the design. Patients at risk for depression received a 6âweek, 5âhour intervention with daily exercises. Intervention targets were assessed at baseline, before each session, and 4âweeks post intervention. Mixed effects analysis of variance (ANOVA) assessed change over the followâup period, controlling for age, partnered status, and disease stage.
Results
Fiftyâfive percent (40/72) of women screened within 6 months of diagnosis had elevated depression risk. Of these, 24 (60%) signed consent. Sixteen received intervention after five were excluded for current depressive disorder, cognitive impairment, or death. Three dropped out. Ninetyâeight percent attendance and 77% practice days indicated feasibility. Effect sizes (Cohen's d) corrected for regression to the mean (RTM) were 0.82 for cancerârelated acceptance coping, 0.65 for cancerârelated emotional expression, and 0.32 and 0.42 for decreased cancerârelated avoidance coping and depressive symptoms, respectively. Effect sizes for variables lacking data to correct for RTM were 1.0, 0.7, and 0.5 for decreased rumination, experiential avoidance, and fear of depression, respectively, and 1.3, 0.6, and 0.4 for increased cognitive flexibility, distress tolerance, and describing/not judging emotions, respectively.
Conclusions
The feasibility of this intervention and malleability of its targets support its further investigation.