Copeptin in critical illness

Latronico, Nicola; Castioni, Carlo Alberto

doi:10.1515/cclm-2014-0529

Cited by 8 publications

(5 citation statements)

References 27 publications

(25 reference statements)

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“…Copeptin secretion is associated with a reactive response to important changes in blood volume, as seen in septic and haemorrhagic shock [ 25 ]; in the present study the septic shock group and the control group of patients with GI bleeding have high levels of copeptin plasma concentrations. It cannot be excluded, however, that proinflammatory stimuli and activation of the immune system can induce the increase of copeptin concentrations in septic shock, as in the case of procalcitonin, since it has been shown that inflammatory mediators such as interleukin-1 β (IL-1 β ) and Tumor Necrosis Factor- α (TNF α ) stimulate the secretion of AVP and copeptin [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis

Battista¹,

Audisio²,

Galluzzo³

et al. 2016

BioMed Research International

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The diagnostic and prognostic usefulness of copeptin were evaluated in septic patients, as compared to procalcitonin assessment. In this single centre and observational study 105 patients were enrolled: 24 with sepsis, 25 with severe sepsis, 15 with septic shock, and 41 controls, divided in two subgroups (15 patients with gastrointestinal bleeding and 26 with suspected SIRS secondary to trauma, acute coronary syndrome, and pulmonary embolism). Biomarkers were determined at the first medical evaluation and thereafter 24, 48, and 72 hours after admission. Definitive diagnosis and in-hospital survival rates at 30 days were obtained through analysis of medical records. At entry, copeptin proved to be able to distinguish cases from controls and also sepsis group from septic shock group, while procalcitonin could distinguish also severe sepsis from septic shock group. Areas under the ROC curve for copeptin and procalcitonin were 0.845 and 0.861, respectively. Noteworthy, patients with copeptin concentrations higher than the threshold value (23.2 pmol/L), calculated from the ROC curve, at admission presented higher 30-day mortality. No significant differences were found in copeptin temporal profile among different subgroups. Copeptin showed promising diagnostic and prognostic role in the management of sepsis, together with its possible role in monitoring the response to treatment.

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Section: Discussionmentioning

confidence: 99%

Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis

Battista¹,

Audisio²,

Galluzzo³

et al. 2016

BioMed Research International

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“…14,20 Copeptin is released in an equimolar ratio to AVP and is more stable in the blood and easy to determine. 7,14,20 The exact role of copeptin has not been elucidated yet. However, it has been suggested that copeptin may play a role in the process of AVP precursor production.…”

mentioning

confidence: 99%

Endocrine dysfunction in sepsis: a beneficial or deleterious host response?

Gheorghiță¹,

Gheorghiu

et al. 2015

GERMS

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Sepsis is a systemic, deleterious inflammatory host response triggered by an infective agent leading to severe sepsis, septic shock and multi-organ failure. The host response to infection involves a complex, organized and coherent interaction between immune, autonomic, neuroendocrine and behavioral systems. Recent data have confirmed that disturbances of the autonomic nervous and neuroendocrine systems could contribute to sepsis-induced organ dysfunction.Through this review, we aimed to summarize the current knowledge about the endocrine dysfunction as response to sepsis, specifically addressed to vasopressin, copeptin, cortisol, insulin and leptin. We searched the following readily accessible, clinically relevant databases: PubMed, UpToDate, BioMed Central.The immune system could be regarded as a "diffuse sensory organ" that signals the presence of pathogens to the brain through different pathways, such as the vagus nerve, endothelial activation/dysfunction, cytokines and neurotoxic mediators and the circumventricular organs, especially the neurohypophysis. The hormonal profile changes substantially as a consequence of inflammatory mediators and microorganism products leading to inappropriately low levels of vasopressin, sick euthyroid syndrome, reduced adrenal responsiveness to ACTH, insulin resistance, hyperglycemia as well as hyperleptinemia.In conclusion, clinical diagnosis of this "pan-endocrine illness" is frequently challenging due to the many limiting factors. The most important benefits of endocrine markers in the management of sepsis may be reflected by their potential to be used as biomarkers in different scoring systems to estimate the severity of the disease and the risk of death.

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“…AVP circulating levels increase during progression to septic shock, so it offers a high diagnostic correlation with sepsis severity and prognosis. [92][93][94][95]…”

Section: Neuroendocrine Systemmentioning

confidence: 99%

Systemic inflammation and sepsis. Part II: Functional consequences of the storm

Dartiguelongue

2021

Arch Argent Pediat

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Copeptin in critical illness

Cited by 8 publications

References 27 publications

Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis

Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis

Endocrine dysfunction in sepsis: a beneficial or deleterious host response?

Systemic inflammation and sepsis. Part II: Functional consequences of the storm

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