Copeptin as an Inflammatory Marker in Diagnosis and Prognosis of Community Acquired Pneumonia in Children

Abstract

A pertinent issue in the administration of pneumonic contaminations is the low explicitness of clinical side effects for the specific determination and the need of anti-infection treatment. A perfect biomarker for bacterial pneumonic diseases ought to permit a quick conclusion, have a prognostic esteem and encourage restorative dynamic.. The mix of a few biomarkers reflecting distinctive pathophysiological pathways can possibly improve the administration of network gained pneumonia later on. I-Inclusion criteriaAll enrolled patients were:  Admitted in pediatric ward and PICU aged between 1 month and18 years old (both males and females).  Children with diagnosis of pneumonia. II-Exclusion criteriaAny patient was excluded from this study if:  Children with any chronic chest illness other than pneumonia .  patients with renal impairment.  Patients with liver impairment.  patients below one month and above 18 years. Study50 children aged from 2 months to 18 years with mean age (54.32± 39.53 (4-120) They were 28 males (56%) and 22 females(44%).Parental consent was granted in all cases and two children died after examination.Their diagnosis based on clinical, laboratory, radiological evaluation. MethodsAll studied patients have been subjected to the following: Demographic data including: I-Full history taking in the form of applied questionnaire includin Sample  Personal history: age, sex, residence.  Onset, duration of illness.  Presenting symptoms: fever, cough, tachypnea, cyanosis, recurrent attacks and congenital anomalies .  Medication received  Outcome 142 Copeptin as an Inflammatory Marker in Diagnosis and Prognosis of Community Acquired Benha Journal Of Applied Sciences, Vol.(5) Issue(5) Part (1) (2020) II -Full clinical examination in the form of:- General examination  General look Vital signs Temperature, heart rate, respiratory rate, blood pressure, capillary refill Oxygen saturation Anthropometric measurements (Head circumference, weight, height)  Systemic examination for  Cardiac systemInspection and palpation to detect the presence of pericardial bulge, pulsations and to examine apex.Auscultation: for heart sounds and audible murmur. Respiratory system Inspection: to detect retractions, chest movements and signs of respiratory distress.  palpation: for tracheal shift and palpable ronchi.  Auscultation: for air entry , breath sounds and advential sound(fine crepitations and wheez) Neurological examination  Assessment of conscious level by Galscow coma scale.  Examination of muscle power, tone and reflexes. Abdominal examination  Inspection: for abdominal distention  Palpation: for organomegaly (hepatomegaly and/ or splenomegaly)  Percussion: for ascites.  Auscultation: for intestinal sound III -Investigations Biochemical and hematological investigations: Measurement of  Complete blood count.  C-reactive protein.  Serum copeptin. 1. Complete blood count (CBC) was done for all samples using sysmex KX-21N (Sysmex Corporation, New York, USA) for red blood cell (RBC) count, hemoglob...