Copeptin and insulin-like growth factor-1 predict long-term outcomes after aneurysmal subarachnoid hemorrhage: A large prospective cohort study

Bian, Liheng; Lin, Jinxi; Liu, Yanfang; Lu, Jingjing; Wang, Wenjuan

doi:10.1016/j.clineuro.2021.106863

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Although there have been numerous studies on the long-term prognosis of aSAH, their definition of long-term prognosis was typically one year after aSAH [ 33 – 37 ]. However, the overburdened risk of mortality in patients with aSAH persists for much longer than one year, necessitating urgent studies on the prognosis of aSAH.…”

Section: Discussionmentioning

confidence: 99%

Association between neutrophil-to-albumin ratio and long-term mortality of aneurysmal subarachnoid hemorrhage

Zhang,

Liu

et al. 2023

BMC Neurol

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Objective The prognosis of aneurysmal subarachnoid hemorrhage (aSAH) survivors is concerning. The goal of this study was to investigate and demonstrate the relationship between the neutrophil-to-albumin ratio (NAR) and long-term mortality of aSAH survivors. Methods A retrospective observational cohort study was conducted at Sichuan University West China Hospital between January 2009 and June 2019. The investigation of relationship between NAR and long-term mortality was conducted using univariable and multivariable Cox regression models. To demonstrate the predictive performance of different biomarkers over time, time-dependent receiver operating characteristic curve (ROC) analysis and decision curve analysis (DCA) were created. Results In total, 3173 aSAH patients were included in this study. There was a strong and continuous relationship between NAR levels and long-term mortality (HR 3.23 95% CI 2.75–3.79, p < 0.001). After adjustment, the result was still significant (adjusted HR 1.78 95% CI 1.49–2.12). Compared with patients with the lowest quartile (< 0.15) of NAR levels, the risk of long-term mortality in the other groups was higher (0.15–0.20: adjusted HR 1.30 95% CI 0.97–1.73; 0.20–0.28: adjusted HR 1.37 95% CI 1.03–1.82; >0.28: adjusted HR 1.74 95% CI 1.30–2.32). Results in survivors were found to be still robust. Moreover, out of all the inflammatory markers studied, NAR demonstrated the highest correlation with long-term mortality. Conclusions A high level of NAR was associated with increased long-term mortality among patients with aSAH. NAR was a promising inflammatory marker for long-term mortality of aSAH.

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Section: Discussionmentioning

confidence: 99%

Association between neutrophil-to-albumin ratio and long-term mortality of aneurysmal subarachnoid hemorrhage

Zhang,

Liu

et al. 2023

BMC Neurol

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“…In recent years, blood copeptin has been recognized as a reliable surrogate marker for severity of disease and adverse outcomes. In adults, it has been shown to predict adverse outcomes in ischemic [ 45 ] and hemorrhagic stroke [ 46 ], heart failure [ 47 ], community-acquired pneumonia [ 48 ], COVID-19 [ 49 ] and many more [ 50 , 51 , 52 ]. In children, copeptin predicted an adverse outcome in community-acquired pneumonia [ 25 , 26 ], congenital heart disease and pulmonary arterial hypertension [ 27 ], perinatal asphyxia [ 28 ], traumatic brain injury [ 31 ] and severity of disease, as well as mortality, in PICU [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Copeptin Release in Arterial Hypotension and Its Association with Severity of Disease in Critically Ill Children

et al. 2022

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Low copeptin levels may indicate inadequate arginine-vasopressin release promoting arterial hypotension, whereas high copeptin concentrations may reflect disease severity. This single-center prospective non-randomized clinical trial analyzed the course of blood copeptin in critically ill normo- and hypotensive children and its association with disease severity. In 164 patients (median age 0.5 years (interquartile range 0.1, 2.9)), the mean copeptin concentration at baseline was 43.5 pmol/L. Though not significantly different after 61 h (primary outcome, mean individual change: −12%, p = 0.36, paired t-test), we detected 1.47-fold higher copeptin concentrations during arterial hypotension when compared to normotension (mixed-effect ANOVA, p = 0.01). In total, 8 out of 34 patients (23.5%) with low copeptin concentrations <10 pmol/L were hypotensive. Copeptin was highest in the adjusted mixed-effect regression analysis within the first day (+20% at 14 h) and decreased significantly at 108 h (−27%) compared to baseline (p = 0.002). Moreover, we found a significant association with vasopressor-inotrope treatment intensity, infancy (1–12 months) and cardiopulmonary bypass (all p ≤ 0.001). In conclusion, high copeptin values were associated with arterial hypotension and severity of disease in critically ill children. This study does not support the hypothesis that low copeptin values might be indicative of arginine-vasopressin deficiency.

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Copeptin and insulin-like growth factor-1 predict long-term outcomes after aneurysmal subarachnoid hemorrhage: A large prospective cohort study

Cited by 2 publications

References 27 publications

Association between neutrophil-to-albumin ratio and long-term mortality of aneurysmal subarachnoid hemorrhage

Association between neutrophil-to-albumin ratio and long-term mortality of aneurysmal subarachnoid hemorrhage

Copeptin Release in Arterial Hypotension and Its Association with Severity of Disease in Critically Ill Children

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