Copeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: the prospective Malmö Diet and Cancer Study cardiovascular cohort

Abstract

Copeptin independently predicts DM and abdominal obesity but not the cluster of MetS. Apart from predicting DM and abdominal obesity, elevated copeptin signals increased risk of microalbuminuria. Interestingly, the association between copeptin and later microalbuminuria was independent of both prevalent and incident DM and hypertension. Our findings suggest a relationship between a dysregulated vasopressin system and cardiometabolic risk, which could have implications for risk assessment and novel preventive treatments.

Copeptin Is Associated with Kidney Length, Renal Function, and Prevalence of Simple Cysts in a Population-Based Study

“…[43][44][45][46] Other studies estimated eGFR using the Modification of Diet in Renal Disease formula or cystatin C but not the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, which is known to be the most reliable formula. 47,[49][50][51] In our study, we observe an inverse linear association with copeptin levels even in participants with normal eGFR and confirm an almost 3 times increased odds of CKD in patients with higher copeptin levels.…”

“…These data support earlier reports in ADPKD, 43 and the general population, although the significance levels were lower in our study. 49,50 This can be due to the higher number of patients in those studies, the fact that the PREVEND study used a cutoff of 10 mg/L albuminuria for inclusion, and the Malmo study analyzed ACR in spot urine instead of 24-hour urine collection. Previous studies have shown an association between albuminuria and urinary concentrating ability in diabetic rats, 54 as well as in healthy rats and humans, 55 suggesting that increased AVP has a proalbuminuric effect.…”

“…49 In 2064 participants from the Malmö Diet and Cancer study, baseline circulating copeptin was associated with the incidence of diabetes, obesity, and albuminuria after 16 years of follow-up. 50 In healthy volunteers, eGFR was also found to be an independent predictor of copeptin levels. 51 Some studies have measured GFR using iothalamate, 99m Tc-DTPA, or inulin clearance.…”

“…In that case, models 2 and 3 were adjusted for fasting glucose instead of diabetes, as done in previous studies. 49,50 To generate the panels in Figure 2, for each dependent variable separately, we first generated adjusted residuals from mixed linear models, including age, sex, and center as covariates, and then scaled them by adding the mean of the dependent variable. In Figure 3, we generated the adjusted predicted probability of cyst at selected levels of log-transformed copeptin, including age, sex, and center as covariates in the model, using the margin function in Stata.…”

Antagonism of vasopressin V2 receptor improves albuminuria at the early stage of diabetic nephropathy in a mouse model of type 2 diabetes

“…Cross-sectional and prospective studies in the general population have shown associations between plasma copeptin and albuminuria or renal function decline (Meijer et al, 2010;Enhorning et al, 2013;Roussel et al, 2015). High circulating copeptin concentration was also associated with the development and progression of diabetic nephropathy in patients with type 2 diabetes (Boertien et al, 2013;Velho et al, 2013;Hu et al, 2015;Pikkemaat et al, 2015;Zhu et al, 2016), and with prevalence of ESRD in subjects with long-standing type 1 diabetes (Bjornstad et al, 2016;Velho et al, 2016).…”