Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion

Sillesen, Anne-Sophie; Raja, Anna Axelsson; Pihl, Christian; Vøgg, R. Ottilia B.; Hedegaard, Morten; Emmersen, Pernille; Sundberg, Karin; Tabor, Ann; Vedel, C.; Zingenberg, Helle; Kruse, Charlotte; Wilken‐Jensen, Charlotte; Nielsen, Toke Rammer; Jørgensen, Finn Stener; Jeppesen, Dorthe Lisbeth; Søndergaard, Lars; Kamstrup, Pia R.; Nordestgaard, Børge G.; Frikke‐Schmidt, Ruth; Vejlstrup, Niels; Boyd, Heather A.; Bundgaard, Henning; Iversen, Kasper

doi:10.1007/s10654-018-0448-y

Cited by 37 publications

(33 citation statements)

References 48 publications

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“…A more correct prevalence of VSDs can be found with a large, prospective cohort study performing an echocardiogram on all newborns. The Copenhagen Baby Heart Study did just that, and we are awaiting the results to be published 30 …”

Section: Discussionmentioning

confidence: 98%

Prenatally detected isolated ventricular septum defects and the association with chromosomal aberrations—A nationwide register‐based study from Denmark

et al. 2020

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Objective To evaluate the association between prenatally detected isolated ventricular septum defects (VSDs) and chromosomal aberrations in a nationwide study in Denmark. Method Nationwide, register‐based study with prospectively collected data including all singleton pregnancies from 2014‐2018. From the Danish Fetal Medicine Database, we retrieved data on maternal characteristics, first‐trimester biomarkers, pre‐ and postnatal diagnoses, genetic test results, and pregnancy outcomes. VSDs were considered isolated in the absence of other malformations or soft markers, and with a low first‐trimester risk assessment for trisomies 21, 18 and 13. All cases of an isolated VSD with a chromosomal anomaly were audited. The genetic tests included karyotyping and chromosomal microarray. Results We retrieved data on 292 108 singleton pregnancies; 323 registered with a prenatally detected VSD and 697 with a VSD detected postnatally (incidence of 0.35%). Only 1/153 (0.7%, 95% CI 0.02;3.6%) of the isolated prenatally detected VSDs had an abnormal genetic test result (del (8)(q23.1)). Moreover, they had a lower free β‐hCG MoM (0.9 MoM vs 0.99 MoM, P = 0.02), and were more likely born small for gestational age (SGA), defined as birthweight 2 or more SD below the mean, compared with the control population (5.2% vs 2.5%, P = 0.03). Conclusion We found a prevalence of chromosomal aberrations of 0.7% in fetuses with a prenatally detected isolated VSD. Moreover, we found an association between isolated VSDs and a larger proportion being born SGA.

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Section: Discussionmentioning

confidence: 98%

Prenatally detected isolated ventricular septum defects and the association with chromosomal aberrations—A nationwide register‐based study from Denmark

et al. 2020

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“…The Copenhagen Baby Heart Study is a multicenter, prospective, population-based cohort study, and all newborns from April 2016 to October 2018 born in the 3 largest maternity wards in the Copen-hagen area -Rigshospitalet, Herlev Hospital, and Hvidovre Hospital -were offered inclusion in the project [13,14]. The 3 hospitals are public and serve a diverse population with mixed socioeconomic backgrounds.…”

Section: Methodsmentioning

confidence: 99%

The Evolution of the Neonatal QRS Axis during the First Four Weeks of Life

et al. 2021

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Background: The QRS axis represents the sum and orientation of the ventricular depolarization. Accurate interpretation of abnormalities in the QRS axis may facilitate early diagnosis of heart disease in newborns. We aimed at describing the evolution of the QRS axis during the first 4 weeks of life and provide reference values from healthy newborns. Methods: The Copenhagen Baby Heart Study is a prospective general population study that offered cardiac evaluation during the first month of life to all newborns delivered in the Copenhagen area. Results: Electrocardiograms from 12,317 newborns (52% boys; mean age 12 days) with normal echocardiograms were included. The median QRS axis was 119° at the ages 0–7 days and shifted leftward to 102° at the ages 22–28 days (p < 0.001). We found that girls had a significantly less pronounced right-shifted axis than boys (p < 0.001) and that increasing gestational age (GA) was associated with a more pronounced right-shifted axis (p < 0.05). Infant size did not affect the axis (p > 0.05). Only 0.5% had an axis within the interval 0 to −90° and 1.1% in the interval +240 to +30°. Conclusions: The QRS axis showed a gradual leftward-shift during the first 4 weeks of life and was affected by sex and GA but unaffected by infant size. Less than 1% of the newborns had a QRS axis between 0 and −90°. This study represents updated reference values, which may facilitate the clinical handling of newborns.

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“…The echocardiographic protocol in CBHS included standard subxiphoid, apical, parasternal, and suprasternal views obtained in accordance with guidelines. 16,19 Images were acquired using Vivid E9 ultrasound machines (General Electric, Horten, Norway) and cardiac probes 12S-D and 6S-D. The images were stored digitally and analyzed offline using EchoPac software version 113 (General Electric, Horten, Norway).…”

Section: Echocardiographymentioning

confidence: 99%

Prevalence of Left Ventricular Noncompaction in Newborns

Børresen

Blixenkrone-Møller

Kock

et al. 2022

Circ: Cardiovascular Imaging

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Background: Left ventricular noncompaction (LVNC) is characterized by excessive trabeculations of the LV and may be associated with reduced systolic function or severe adverse outcomes. Several aspects remain to be elucidated; there is controversy to whether LVNC cardiomyopathy is a distinct cardiomyopathy caused by failure of the spongy fetal myocardium to condense during fetal development or acquired later in life as a morphological trait associated with other types of cardiomyopathy; the prevalence in unselected populations is unknown and the distinction between normal variation and pathology remains to be defined. In this study, we aimed to determine the prevalence of LVNC and the association to LV systolic function in a large, population-based cohort of neonates. In addition, we assessed the normal ratio of noncompact to compact (NC:C) myocardium in 150 healthy neonates. Methods: Echocardiographic data were prospectively collected in the population study Copenhagen Baby Heart Study. The ratio of NC:C was measured in 12 ventricular segments. LVNC was defined as NC:C ≥2 in at least one segment. Neonates with LVNC were matched 1:10 to controls on sex, gestational age, and weight and age at the examination day. Results: In total, 25 590 neonates (52% males, median age 11 [interquartile range, 7–15] days) underwent echocardiography. Among 21 133 with satisfactory visualization of ventricular segments, we identified a prevalence of LVNC of 0.076% (95% CI, 0.047–0.123). LV ejection fraction was lower in neonates with LVNC compared with matched controls (median 49.5 versus 59.0%; P <0.0001). In neonates with otherwise healthy hearts, the median NC:C ratio ranged from 0.0 to 0.7 and the 99th percentiles from 1.0 to 1.9 for each of the 12 segments. Conclusions: The prevalence of LVNC based on neonatal echocardiography was 0.076%. LVNC was associated with lower LV systolic function. The findings in normal newborns support the cutoff NC:C ≥2 as an appropriate diagnostic criterion. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02753348.

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Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion

Cited by 37 publications

References 48 publications

Prenatally detected isolated ventricular septum defects and the association with chromosomal aberrations—A nationwide register‐based study from Denmark

Prenatally detected isolated ventricular septum defects and the association with chromosomal aberrations—A nationwide register‐based study from Denmark

The Evolution of the Neonatal QRS Axis during the First Four Weeks of Life

Prevalence of Left Ventricular Noncompaction in Newborns

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